The PMS2 post meiotic segregation increased 2 (PMS2) gene is located on chromosome number 7.1 PMS2 functions, along with MSH2, MLH1, and MSH6, as part of the DNA mismatch repair (MMR) pathway, are utilized by normal proliferating cells to repair mutations that may occur during DNA replication. The gene product of PMS2 forms a heterodimer […]
Templates Download CK HMW + p63 + AMACR (RM) Download Ber-EP4 Download MOC-31 Download CD4 + CD8 Download Mouse Amp AP Detection Download Mouse-on-Canine HRP-Polymer Download Mouse-on-Mouse AP-Polymer Download Mouse-on-Mouse HRP-Polymer Download Mouse-on-Rat HRP-Polymer Download Mouse-on-Rat AP-Polymer Download Ki-67 Rb – Vina Green Download Ki-67 Rb – Deep Space Black Download ONCORE Pro X Hematoxylin […]
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Approximately 150,000 men and women in the United States are diagnosed with colorectal cancer annually, leading to an annual estimated 51,000 deaths.1 Colorectal cancers are the third-most common in the United States (excluding skin cancer), with about 8.1% of new cancer cases diagnosed, contributing to approximately 8.3% of cancer deaths yearly.1 Worldwide, colorectal cancers are […]
![Colorectal carcinoma stained with MSH6 [BC19]](https://biocare.net/wp-content/uploads/3215_MSH6-BC19.jpg)
MSH6 functions, along with MSH2, MLH1, and PMS2, as part of the DNA mismatch repair (MMR) pathway, are utilized by normal proliferating cells to repair mutations that may occur during DNA replication.16 MSH6 is a heterodimer of MSH2 and binds to DNA containing G/T mismatches. The MSH2-MSH6 complex recognizes a single-based mispair insertion/deletion loop.15,16 Antibodies […]
![Colorectal carcinoma stained with MLH-1 [BC23]](https://biocare.net/wp-content/uploads/3214_MLH-1-BC23.jpg)
The BC23 antibody recognizes human and mouse MLH1 (80-85 kDa). The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI) (1-3). These defects in […]
References: 1. Bellizzi, AM & Frankel WL. Adv Anat Pathol 2009;16:405 2. Shia, J. J Mol Diagn 2008;10:293 3. Backes, FJ, et al. Gynecologic Oncol 2009;114:486
Carcinoembryonic Antigen Carcinoembryonic Antigen (CEA {P}) CDX2 Cytokeratin 20 D2-40 DOG1 Helicobacter pylori Ki-67 (M) Ki-67 MLH-1 MSH2 MSH6 Mucin 5AC p53 Pan Cytokeratin [AE1/AE3] Pan Cytokeratin [Lu-5] Pan Cytokeratin Plus [AE1/AE3 + 8/18] PMS2 Villin CDX2 + CK7 D2-40 + CD31 D2-40 + Ki-67
MSH6 functions, along with MSH2, MLH1, and PMS2, as part of the DNA mismatch repair (MMR) pathway, are utilized by normal proliferating cells to repair mutations that may occur during DNA replication.16 MSH6 is a heterodimer of MSH2 and binds to DNA containing G/T mismatches. The MSH2-MSH6 complex recognizes a single-based mispair insertion/deletion loop.1,2 Antibodies […]
