P504S, also known as α-Methylacyl coenzyme A racemase (AMACR), is a peroxisomal and mitochondrial enzyme that plays a role in bile acid synthesis and β-oxidation of branched chain fatty acids (1). AMACR was initially identified from a cDNA library as a gene that is over-expressed in human prostate cancer; with little or no expression in […]
CK5 and CK14 are high molecular weight cytokeratins expressed in a variety of normal and neoplastic epithelial tissues. p63, a homolog of the tumor suppressor p53, was detected in nuclei of the basal epithelium in normal prostate glands; however, it was not expressed in malignant tumors of the prostate. Expression of P504S protein is found […]
p63, a homolog of the tumor suppressor p53, has been identified in proliferating basal cells in the epithelial layers of a variety of tissues, including epidermis, cervix, urothelium and prostate.1 p63 was detected in nuclei of the basal epithelium in normal prostate glands; however, it was not expressed in malignant tumors of the prostate.2 P504S, […]
P504S, also known as α-methylacyl coenzyme A racemase (AMACR), is a peroxisomal and mitochondrial enzyme that has been shown to play a role in bile acid synthesis and β-oxidation of branched chain fatty acids. In immunohistochemistry studies, P504S has been shown to be a specific marker of prostatic adenocarcinoma. Additionally, prostate glands involved in PIN […]
P504S, 3X is being discontinued. We will continue to offer these products until 06/30/16 or until current inventory is depleted, whichever occurs first. Biocare does offer P504S (P) or P504S, 2X, catalog numbers ACA200, APA200, AVA200, IPA200 or PP365, IP365 as a substitute. P504S, also known as β-methylacyl coenzyme A racemase (AMACR), is a peroxisomal […]
P504S, also known as α-methylacyl coenzyme A racemase (AMACR), is a peroxisomal and mitochondrial enzyme that plays a role in bile acid synthesis and β-oxidation of branched chain fatty acids.5
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Early on, Biocare recognized the market need for evaluating morphologically distinct markers to aid in solving complex clinical problems and simplifying interpretation, all while conserving precious patient tissue. The most glaring clinical need was determined to be the ability to differentiate between prostatic intraepithelial neoplasia (PIN) and carcinoma of the prostate. There also needed to […]
CK5 and CK14 are high molecular weight cytokeratins expressed in a variety of normal and neoplastic epithelial tissues (1). In prostate tissue, mRNA for CK5 and CK14 has been detected in the basal cells of normal glands and prostatic intraepithelial neoplasia (PIN), a precursor lesion to prostatic adenocarcinoma; however, expression of CK5 or CK14 was […]
