Lung cancer is the leading cause of cancer-related deaths in the United States and worldwide, with non-small cell lung cancer (NSCLC) accounting for 80% of lung cancers.1 NSCLC’s predominate subtypes are adenocarcinomas (ADC) and squamous cell carcinomas (SCC).1 Therapy of NSCLC depends on accurate histological classifications of these two subclassifications.1 Differentiating the two can be […]
14
Apr
Apr
TTF-1 has been the premier marker for lung adenocarcinoma. Another promising marker, Napsin A, is expressed in type II pneumocytes and in adenocarcinomas of the lung (1). Studies have shown Napsin A to be more sensitive and specific than TTF-1 in lung adenocarcinomas, and virtually negative in all squamous carcinomas. In other studies, comparing TTF-1 […]
13
Mar
Mar
Desmoglein 3 (DSG3) is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily (1,2). Desmogleins exhibit membranous expression and connect with cytokeratins through desmoplakins and plakoglobin. DSG3 is particularly important in the cellular adhesion […]
11
Apr
Apr
Napsin A (P), 2X is being discontinued. We will continue to offer these products until 06/30/16 or until current inventory is depleted, whichever occurs first. Biocare does offer Napsin A or Napsin A (RM), catalog numbers PP434 or ACI3043, API3043 as a substitute. Napsin A antibody is a pepsin-like aspartic proteinase. It is expressed in […]
11
Mar
Mar
TTF-1 is a member of the NKX2 family of homeodomain transcription factors found in epithelial cells of the thyroid gland and lung. TTF-1 has been shown to stain approximately 65-70% of cases of lung adenocarcinomas (ADC), with a small number of cases of lung squamous cell carcinoma (SCC) also positive for TTF-1 (1-4). Napsin A […]
01
Oct
Oct
TTF-1 has been the premier marker for lung adenocarcinoma. A new and promising marker, Napsin A, is expressed in type II pneumocytes and in adenocarcinomas of the lung (2). Studies have shown Napsin A to be more sensitive and specific than TTF-1 in lung adenocarcinomas and virtually negative in all squamous carcinomas. In other studies […]
23
Sep
Sep
Napsin A is a pepsin-like aspartic proteinase. It is expressed in type II pneumocytes and in most lung adenocarcinomas and some renal cell carcinomas. Studies have shown that Napsin A is a more sensitive and specific marker than TTF-1 and is extremely specific for lung adenocarcinomas (1-6). Most studies show Napsin A is highly specific […]
23
Sep
Sep
Napsin A is a pepsin-like aspartic proteinase. It is expressed in type II pneumocytes and in adenocarcinomas of the lung and kidney.15,16 Studies have shown that Napsin A is extremely specific for lung adenocarcinomas. Most studies show Napsin A is a sensitive and specific marker for aiding in the discrimination between lung squamous cell carcinoma […]
23
Sep
Sep
Napsin A is a pepsin-like aspartic proteinase. It is expressed in type II pneumocytes and in adenocarcinomas of the lung and kidney.15
17
Sep
Sep
Desmoglein 3 (DSG3) + Napsin A are very sensitive and specific markers, and may be useful for discriminating between lung SqCC and lung adenocarcinoma. DSG3 is a membrane stain that marks lung SqCC while Napsin A is a cytoplasmic stain that marks lung adenocarcinomas. In the vast majority of lung cancers tested, only a single […]
