![Prostate cancer stained with NKX3.1 [D2Y1A] antibody](https://biocare.net/wp-content/uploads/3260.jpg)
NKX3.1 is located in chromosome 8p and encodes a homeodomain transcription factor whose expression is largely restricted to the prostate and controlled by the androgen hormone.1 Loss of function of NKX3.1 results in human prostrate carcinoma and prostatic intraepithelial neoplasia (PIN). NKX3.1 stains nuclei in both normal and prostate cancer providing a robust stain that […]
NKX3.1 (RM) is currently on backorder, please use the recommended replacement NKX3.1: https://biocare.net/product/nkx3-1-antibody/ NKX3.1 is a protein found in humans and is encoded by the NKX3.1 gene located on chromosome 8 (1). The homeodomain containing transcription factor NKX3A is a putative prostate tumor suppressor that is expressed in a largely prostate-specific and androgen-regulated manner. NKX3.1 […]
The prostein gene encodes a 553-amino acid type IIIa plasma membrane protein with a cleavable signal peptide and 11 transmembrane-spanning regions (1). IHC analysis has demonstrated that the Prostein antibody (also known as P501S) was expressed in the normal prostate tissue and the vast majority of malignant prostatic tissues, regardless of grade and metastatic status […]
NKX3.1 is a protein found in humans and is encoded by the NKX3.115 gene located on chromosome 8.15 The homeodomain containing transcription factor NKX3A is a putative prostate tumor suppressor that is expressed in a largely prostate-specific and androgen-regulated manner.15,16 NKX3.1 protein has been found to be positive in the vast majority of primary prostatic […]
NKX is a prostate-specific tumor suppressor gene and loss of a single allele may predispose to prostate carcinogenesis (1). Studies have shown that the onset of MYC overexpression and the subsequent development of prostatic intraepithelial neoplasia coincide with this reduction in NKX (2). Over-expression of MYC has been reported as an early oncogenic event driving […]
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Biocare Medical takes great pride in our promise of “Fighting Cancer, One Slide at a Time.” Our focus in the fight against cancer is realized through our high-quality immunohistochemistry (IHC) and in situ hybridization (ISH) reagents and instrumentation. Specifically, our sensitive and specific antibodies, molecular probes, and detection chemistries support early and accurate classification of […]
The prostein gene encodes a 553-amino acid type IIIa plasma membrane protein with a cleavable signal peptide and 11 transmembrane-spanning regions (1). IHC analysis has demonstrated that the Prostein antibody (also known as P501S) was expressed in the vast majority of normal and malignant prostatic tissues, regardless of grade and metastatic status. Prostein expression was […]
NKX is a prostate-specific tumor suppressor gene and loss of a single allele may predispose to prostate carcinogenesis1. Studies have shown that the onset of MYC over expression and the subsequent development of prostatic intraepithelial neoplasia coincide with this reduction in NKX2 . Over-expression of MYC has been reported as an early oncogenic event driving […]
