![Colorectal carcinoma stained with MSH6 [BC19]](https://biocare.net/wp-content/uploads/3215_MSH6-BC19.jpg)
MSH6 functions, along with MSH2, MLH1, and PMS2, as part of the DNA mismatch repair (MMR) pathway, are utilized by normal proliferating cells to repair mutations that may occur during DNA replication.16 MSH6 is a heterodimer of MSH2 and binds to DNA containing G/T mismatches. The MSH2-MSH6 complex recognizes a single-based mispair insertion/deletion loop.15,16 Antibodies […]
MSH6 functions, along with MSH2, MLH1, and PMS2, as part of the DNA mismatch repair (MMR) pathway, are utilized by normal proliferating cells to repair mutations that may occur during DNA replication.16 MSH6 is a heterodimer of MSH2 and binds to DNA containing G/T mismatches. The MSH2-MSH6 complex recognizes a single-based mispair insertion/deletion loop.1,2 Antibodies […]
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The synergistic relationship of enzyme and HIER For strong, specific staining of difficult antibodies With the increased use of heat-induced epitope retrieval (HIER) for formalin-fixed paraffin-embedded (FFPE) tissues on automated immunohistochemistry (IHC) instruments, enzymatic digestion use has decreased. Automated instruments often lack the capacity to exceed 100°C, resulting in less than optimal results compared to […]
What Tissues Are You Working With?
Approximately 150,000 men and women in the United States are diagnosed with colorectal cancer annually, leading to an annual estimated 51,000 deaths.1 Colorectal cancers are the third-most common in the United States (excluding skin cancer), with about 8.1% of new cancer cases diagnosed, contributing to approximately 8.3% of cancer deaths yearly.1 Worldwide, colorectal cancers are […]
![Colorectal carcinoma stained with MLH-1 [BC23]](https://biocare.net/wp-content/uploads/3214_MLH-1-BC23.jpg)
The BC23 antibody recognizes human and mouse MLH1 (80-85 kDa). The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI) (1-3). These defects in […]
References: 1. Bellizzi, AM & Frankel WL. Adv Anat Pathol 2009;16:405 2. Shia, J. J Mol Diagn 2008;10:293 3. Backes, FJ, et al. Gynecologic Oncol 2009;114:486
Carcinoembryonic Antigen Carcinoembryonic Antigen (CEA {P}) CDX2 Cytokeratin 20 D2-40 DOG1 Helicobacter pylori Ki-67 (M) Ki-67 MLH-1 MSH2 MSH6 Mucin 5AC p53 Pan Cytokeratin [AE1/AE3] Pan Cytokeratin [Lu-5] Pan Cytokeratin Plus [AE1/AE3 + 8/18] PMS2 Villin CDX2 + CK7 D2-40 + CD31 D2-40 + Ki-67
