A monoclonal antibody cocktail targeted against mini-chromosome maintenance protein 2 (MCM2) and DNA topoisomerase IIA (TOP2A), when up regulated, serves as a marker of aberrant S-phase induction in proliferating cells.15 MCM2, as part of a hexameric pre-replication complex, drives the formation of pre-replicative complexes during DNA replication, a critical initial step during G1 phase.16 TOP2A […]
Approximately 13,000 women in the United States are diagnosed with cervical cancer annually, leading to an annual estimated 4,000 deaths.1 Cervical cancers are comparatively rare in the United States, with about 0.8% of new cancer cases classified as cervical, contributing approximately 0.7% of cancer deaths yearly.1 Worldwide, cervical cancer is the fourth most frequently diagnosed […]
BCR (22q11.2) Green FISH Probe is intended to hybridize to the 22q11.2 probe region on chromosome 22. The clinical interpretation of any positive or negative hybridization events should be complemented by the use of appropriate controls and other diagnostic tests where appropriate. Evaluation should be carried out within the context of the patient’s clinical history […]
ABL (9q34.12) Orange FISH Probe is intended to hybridize to the 9q34.12 probe region on chromosome 9. The clinical interpretation of any positive or negative hybridization events should be complemented by the use of appropriate controls and other diagnostic tests where appropriate. Evaluation should be carried out within the context of the patient’s clinical history […]
HPV Probes Download HPV 6 Probe Download HPV 11 Probe Download HPV 16 Probe Download HPV 18 Probe Download HPV 31 Probe Download HPV 51 Probe Download CISH DNA 1 Temp1 Download CISH DNA 2 Temp1 Download ONCORE Pro Warp Red Chromogen Kit Download ONCORE Pro Hematoxylin Download Molecular Probe / Templates Download ALK […]
![Tonsil stained with TIGIT [BC41] antibody](https://biocare.net/wp-content/uploads/3254.jpg)
T-cell immunoglobulin and immunoreceptor tyrosine-based inhibitory domain (TIGIT) is a transmembrane glycoprotein receptor expressed in regulatory and memory T cells, natural killer (NK), and activated T cells (1). As a member of the immunoglobulin superfamily, TIGIT has coinhibitory effects on T-cell dependent immune responses, playing an important role in transplantation tolerance and tumor immune surveillance […]
T-cell immunoglobulin and immunoreceptor tyrosine-based inhibitory domain (TIGIT) is a transmembrane glycoprotein receptor expressed in regulatory and memory T cells, natural killer (NK), and activated T cells (1). As a member of the immunoglobulin superfamily, TIGIT has coinhibitory effects on T-cell dependent immune responses, playing an important role in transplantation tolerance and tumor immune surveillance […]
CD8 [C8/1779R] is a rabbit monoclonal antibody that is intended for laboratory use in the qualitative identification of CD8a protein by immunohistochemistry (IHC) in formalin-fixed paraffin-embedded (FFPE) human tissues. The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of […]
Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) is a member of the CD28 superfamily and is a negative regulator of T cell-mediated immune responses. CTLA-4 expression is induced on the surface of T cells after CD28 binding and activation, and is constitutively expressed on T-regulatory cells, acting as an immune checkpoint inhibitor, downregulating T cell activity. (1-3). […]
