The MART-1/Melan A recognizes a protein of 18 kDa, identified as MART-1 (Melanoma Antigen Recognized by T cells 1) or Melan-A. The MART-1 recognizes a subcellular fraction found in melanosomes. The antibody labels melanomas and tumors showing melanocytic differentiation. It does not mark neoplasms of epithelial origin, lymphomas or mesenchymal tumors. MART-1 is a useful […]
The skin is the largest human body organ. It is comprised of many different layers, each with its own unique function and susceptibility to abnormalities. Melanoma is a deadly skin disease known for its aggressive clinical behavior and high tendency to metastasize.1 Most melanomas can be accurately diagnosed by examining histological features, including asymmetry, lack […]
MART-1 recognizes a protein of 18 kDa, identified at MART-1 (Melanoma Antigen Recognized by T cells 1). MART-1 is a useful addition to melanoma panels as it is specific for melanocytic lesions (1- 3). Studies have shown that MART-1 is more sensitive than HMB45 when labeling metastatic melanomas (3). Tyrosinase is a key enzyme involved […]
CK5 and CK14 are high molecular weight cytokeratins expressed in a variety of normal and neoplastic epithelial tissues (1). In prostate tissue, mRNA for CK5 and CK14 has been detected in the basal cells of normal glands and prostatic intraepithelial neoplasia (PIN), a precursor lesion to prostatic adenocarcinoma; however, expression of CK5 or CK14 was […]
MART-1 recognizes a protein of 18 kDa, identified at MART-1 (Melanoma Antigen Recognized by T cells) (1). MART-1 is a useful addition to melanoma panels as it is apparently specific for melanocytic lesions (1,2). Studies have shown that MART-1 is more sensitive than HMB45 when labeling metastatic melanomas (3). This MART-1 cocktail does not stain […]
MART-1 recognizes an 18 kDa protein (Melanoma Antigen Recognized by T cells 1) and is specific for melanocytic lesions, making it a valuable component of melanoma panels.15-17 MART-1 has been shown to be more sensitive than HMB45 for labeling metastatic melanomas. Tyrosinase, a key enzyme in early melanin biosynthesis, is more sensitive than HMB45 and […]
In normal epithelia, HMW Cytokeratins (CK5 and CK14) stain basal epithelia in the prostate gland.p63 is detected in prostate basal epithelial nuclei in normal prostate, however, is negative in malignant tumors of the prostate gland. Thus p63 is useful as a differential marker for benign and malignant tumors of the prostate gland and can be […]
MART-1 recognizes a protein of 18 kDa, identified at MART-1 (Melanoma Antigen Recognized by T cells).1 MART-1 is a useful addition to melanoma panels as it is apparently specific for melanocytic lesions.1,2 Studies have shown that MART-1 is more sensitive than HMB45 when labeling metastatic melanomas.3 This MART-1 cocktail does not stain steroid tumors. Tyrosinase […]
The HMB45 clone reacts with a neuraminidase-sensitive oligosaccharide side chain of a glycoconjugate present in immature melanosomes. The HMB45-reactive antigen is present in cutaneous melanocytes, prenatal and infantile retinal pigment epithelium and melanoma cells. It is also thought to be oncofetal in nature. This antibody has been shown to label the majority of melanomas. The […]
Studies have shown that in normal epithelia, HMW Cytokeratins (CK5 and CK14) stain stratified epithelia, myoepithelial cells and basal cells in the prostate gland and bronchi.15 p63 is detected in prostate basal cells in normal prostate; however, it is negative in malignant tumors of the prostate gland. Thus, p63 is useful as a differential marker […]
