MART-1 recognizes a protein of 18 kDa, identified at MART-1 (Melanoma Antigen Recognized by T cells 1). MART-1 is a useful addition to melanoma panels as it is specific for melanocytic lesions (1- 3). Studies have shown that MART-1 is more sensitive than HMB45 when labeling metastatic melanomas (3). Tyrosinase is a key enzyme involved […]
MART-1 recognizes an 18 kDa protein (Melanoma Antigen Recognized by T cells 1) and is specific for melanocytic lesions, making it a valuable component of melanoma panels.15-17 MART-1 has been shown to be more sensitive than HMB45 for labeling metastatic melanomas. Tyrosinase, a key enzyme in early melanin biosynthesis, is more sensitive than HMB45 and […]
SOX10 Antibody The SOX10 protein is widely expressed in normal human tissues including melanocytes and breast tissue. It is also an important marker in malignant tumors such as melanoma, breast carcinoma, gliomas and benign tumors such as schwannomas. SOX10 antibody has been shown to be expressed in 97-100% of desmoplastic and spindle cell melanomas and […]
Tyrosinase is a key enzyme involved in the initial stages of melanin biosynthesis. Studies have shown Tyrosinase antibody to be a more sensitive marker for melanoma when compared to HMB45 and MART-1. It has also shown to label a higher percentage of desmoplastic melanomas than HMB45. Unlike HMB45, Tyrosinase does not discriminate between activated or […]
The MART-1/Melan A recognizes a protein of 18 kDa, identified as MART-1 (Melanoma Antigen Recognized by T cells 1) or Melan-A. The MART-1 recognizes a subcellular fraction found in melanosomes. The antibody labels melanomas and tumors showing melanocytic differentiation. It does not mark neoplasms of epithelial origin, lymphomas or mesenchymal tumors. MART-1 is a useful […]
The skin is the largest human body organ. It is comprised of many different layers, each with its own unique function and susceptibility to abnormalities. Melanoma is a deadly skin disease known for its aggressive clinical behavior and high tendency to metastasize.1 Most melanomas can be accurately diagnosed by examining histological features, including asymmetry, lack […]
References: 1. Tacha D, et al. American Society of Dermatopathology, 51st Annual Meeting; Poster #278, Nov 6, 2014. 2. Tacha D, et al. Arch Pathol Lab Med. 2015 Apr;139(4):530-6 3. Vrotsos E, Alexis J. Appl Immunohistochem Mol Morphol. 2016 Jan;24(1):26-9. 4. Willis BC, et al. Appl Immunohistochem Mol Morphol. 2015 Feb;23(2):109-12. 5. Clevenger J, et […]
BCR (22q11.2) Green FISH Probe is intended to hybridize to the 22q11.2 probe region on chromosome 22. The clinical interpretation of any positive or negative hybridization events should be complemented by the use of appropriate controls and other diagnostic tests where appropriate. Evaluation should be carried out within the context of the patient’s clinical history […]
ABL (9q34.12) Orange FISH Probe is intended to hybridize to the 9q34.12 probe region on chromosome 9. The clinical interpretation of any positive or negative hybridization events should be complemented by the use of appropriate controls and other diagnostic tests where appropriate. Evaluation should be carried out within the context of the patient’s clinical history […]
