Studies have shown CD45 recognizes an antigen found on lymphoid cells. Most neoplastic B-cells and T-cells stain positively in leukemia and in non Hodgkin’s lymphomas; whereas most neoplastic myeloid and erythroid cells are negative.15-17
CK5 and CK14 are high molecular weight cytokeratins expressed in a variety of normal and neoplastic epithelial tissues (1). In prostate tissue, mRNA for CK5 and CK14 has been detected in the basal cells of normal glands and prostatic intraepithelial neoplasia (PIN), a precursor lesion to prostatic adenocarcinoma; however, expression of CK5 or CK14 was […]
Thyroglobulin antibody cocktail has been shown to react with human thyroglobulin, staining thyroglobulin in follicular epithelial cells as well as colloid tissue. Clones 2H11+ 6E1 have been shown to be useful in positive identification of both papillary and follicular types of thyroid carcinomas. Demonstration of thyroglobulin staining via immunohistochemistry in a metastatic lesion establishes the […]
S100 belongs to the family of calcium binding proteins such as calmodulin and troponin C. The S100 Protein Cocktail antibody stains melanocytes, schwannomas, peripheral neural tissue, astrocytes, benign and malignant melanomas and their metastases. S100 protein is also expressed in the antigen presenting cells such as the Langerhan’s cells in skin and interdigitating reticulum cells […]
PSA is a chymotrypsin-like serine protease (kallikrein family) produced by the prostate epithelium.15-17
In normal epithelia, HMW Cytokeratins (CK5 and CK14) stain basal epithelia in the prostate gland.p63 is detected in prostate basal epithelial nuclei in normal prostate, however, is negative in malignant tumors of the prostate gland. Thus p63 is useful as a differential marker for benign and malignant tumors of the prostate gland and can be […]
MART-1 recognizes a protein of 18 kDa, identified at MART-1 (Melanoma Antigen Recognized by T cells).1 MART-1 is a useful addition to melanoma panels as it is apparently specific for melanocytic lesions.1,2 Studies have shown that MART-1 is more sensitive than HMB45 when labeling metastatic melanomas.3 This MART-1 cocktail does not stain steroid tumors. Tyrosinase […]
Pan Lymphoma Cocktail (LCA + CD20 + CD3 + CD43) are specific leukocyte markers used in the identification and assessment of lymphoid neoplasms. This combination of antibodies offers a marker for the identification of a variety of leukocytes. CD45 also known as leucocyte common antigen (LCA), is expressed on hematopoietic cell lines, but absent on […]
Leukocyte Common Antigen Antibody recognizes an antigen found on lymphoid cells. It reacts with B cells, T-cell subtypes, monocytes, macrophages, and is weakly expressed with granulocytes. The PD7/26 antibody was included in the 3rd International Workshop. CD45RB reacts with 3 of the 5 glycoproteins in the CD45 family (MW 190, 205 and 220 kDa). It […]
Studies have shown that in normal epithelia, HMW Cytokeratins (CK5 and CK14) stain stratified epithelia, myoepithelial cells and basal cells in the prostate gland and bronchi.15 p63 is detected in prostate basal cells in normal prostate; however, it is negative in malignant tumors of the prostate gland. Thus, p63 is useful as a differential marker […]
