30
Sep
Sep
PSA is a chymotrypsin-like serine protease (kallikrein family) produced by the prostate epithelium.15-17
23
Sep
Sep
The Muscle Specific Actin antibody [HHF35] recognizes muscle specific alpha and gamma actin isomers. It does not react with non-muscle actin. Studies have shown that it recognizes the alpha actin from cardiac, skeletal and smooth muscle sources. It does not react with beta or non-smooth muscle gamma actin isomers. The antibody labels leiomyoma, leiomyosarcoma, angiomyolipoma […]
20
Sep
Sep
Leukocyte Common Antigen Antibody recognizes an antigen found on lymphoid cells. It reacts with B cells, T-cell subtypes, monocytes, macrophages, and is weakly expressed with granulocytes. The PD7/26 antibody was included in the 3rd International Workshop. CD45RB reacts with 3 of the 5 glycoproteins in the CD45 family (MW 190, 205 and 220 kDa). It […]
20
Sep
Sep
Studies have shown CD45 recognizes an antigen found on lymphoid cells. Most neoplastic B-cells and T-cells stain positively in leukemia and in non Hodgkin’s lymphomas; whereas most neoplastic myeloid and erythroid cells are negative.15-17
18
Sep
Sep
Hepatocyte Specific Antigen (HSA) is considered specific for normal and neoplastic hepatocytes.15 Expression has been demonstrated consistently in the majority of hepatocellular carcinomas.15,17,18 Studies have shown HSA can be used in a panel with Glypican-3, CEA, CK7, AFP and CD10.16,18
![Breast cancer stained with Epithelial Membrane Antigen (EMA) [E29]](https://biocare.net/wp-content/uploads/3038.jpg)
17
Sep
Sep
The Biocare Epithelial Membrane Antigen (EMA) antibody recognizes a heterogeneous family of highly glycosylated transmembrane proteins known as human milk fat globule (HMFG) membrane proteins. Although originally identified in breast tissue, EMA expression is also found in secretory epithelial cells, to a lesser degree in non-secretory epithelium (e.g., squamous epithelium), and rarely in non-epithelial cells.15,18 […]
12
Dec
Dec
Transducin-like enhancer of split 1 (TLE1) is a member of the TLE family of transcriptional co-repressors that control the transcription of a wide range of genes and has been implicated in embryogenesis, hematopoiesis, and neuronal and terminal epithelial differentiation.15 TLE1 is involved in the Wnt/β-catenin signaling pathway, which is important in synovial sarcomas, and in […]
07
May
May
Probe Enhancer (RNA) is an ancillary reagent that is used as a diluent for RNA targeting probes in an ISH procedure. Probe Enhancer (RNA) facilitates spreading of probes and reduces drying of RNA during hybridization reactions. Effective hybridization may facilitate enhanced staining and reduce artifacts.
22
Mar
Mar
Insulinoma-associated protein 1 (INSM1), a zinc-finger transcription factor, is a key regulator of neuroendocrine differentiation during development, and has recently emerged as a reliable immunostaining marker with a nuclear staining pattern for the identification of neuroendocrine and neuroepithelial neoplasms.15,16 Several studies have demonstrated nuclear INSM1 expression in multiple neuroendocrine tumor types, including small cell carcinomas […]
