Melanomas are a heterogeneous group of tumors (neoplasms) that develop in the melanocytes, the pigment-producing cells in the skin. Accurate diagnosis of these disease states is essential for proper management and prognosis, and immunohistochemistry (IHC) has been a longstanding tool for this purpose. MART-1/MelanA and HMB45 are two commonly used IHC markers for melanoma, though […]
The HMB45 clone reacts with a neuraminidase-sensitive oligosaccharide side chain of a glycoconjugate present in immature melanosomes. Studies have shown the HMB45-reactive antigen is present in cutaneous melanocytes, prenatal and infantile retinal pigment epithelium and melanoma cells. It is also thought to be oncofetal in nature.15 The MART-1/Melan A recognizes a protein of 18kDa, identified […]
HMB45 reacts with a neuraminidase-sensitive oligosaccharide side chain of a glycoconjugate present in immature melanosomes. The HMB45-reactive antigen is present in cutaneous melanocytes, prenatal and infantile retinal pigment epithelium (RPE), and melanoma cells and is thought to be oncofetal in nature. This antibody has been shown to label the majority of melanomas.15
HPV Probes Download HPV 6 Probe Download HPV 11 Probe Download HPV 16 Probe Download HPV 18 Probe Download HPV 31 Probe Download HPV 51 Probe Download CISH DNA 1 Temp1 Download CISH DNA 2 Temp1 Download ONCORE Pro Warp Red Chromogen Kit Download ONCORE Pro Hematoxylin Download Molecular Probe / Templates Download ALK […]
The skin is the largest human body organ. It is comprised of many different layers, each with its own unique function and susceptibility to abnormalities. Melanoma is a deadly skin disease known for its aggressive clinical behavior and high tendency to metastasize.1 Most melanomas can be accurately diagnosed by examining histological features, including asymmetry, lack […]
Increased Staining Consistency and Clarity on the ONCORE Pro X for Multiplex Staining Download pdf Clone Wars – CDX2 – Comparative Analysis Download pdf Understanding FISH vs NGS Capabilities Download pdf FLet’s Get Clinical: Understanding Mismatch Repair and Microsatellite Instability Download pdf FISH and Cytogenetic Analysis: Probing for CLL and MDS Download pdf Probing Questions: […]
![Melanoma Stained with S100 Protein [4C4.9] (M)](https://biocare.net/wp-content/uploads/3237-1.jpg)
S100 recognizes proteins of 21-24 kDa, identified as the A and B subunits of S100 protein. S100 belongs to the family of calcium binding proteins such as calmodulin and troponin C. S100A is composed of an alpha and beta chain whereas S100B is composed of two beta chains. S100 protein is expressed in Schwannomas, ependymomas, […]
Biocare Medical takes great pride in our promise of “Fighting Cancer, One Slide at a Time.” Our focus in the fight against cancer is realized through our high-quality immunohistochemistry (IHC) and in situ hybridization (ISH) reagents and instrumentation. Specifically, our sensitive and specific antibodies, molecular probes, and detection chemistries support early and accurate classification of […]
MART-1 recognizes a protein of 18 kDa, identified at MART-1 (Melanoma Antigen Recognized by T cells 1). MART-1 is a useful addition to melanoma panels as it is specific for melanocytic lesions (1- 3). Studies have shown that MART-1 is more sensitive than HMB45 when labeling metastatic melanomas (3). Tyrosinase is a key enzyme involved […]
MART-1 recognizes a protein of 18 kDa, identified at MART-1 (Melanoma Antigen Recognized by T cells) (1). MART-1 is a useful addition to melanoma panels as it is apparently specific for melanocytic lesions (1,2). Studies have shown that MART-1 is more sensitive than HMB45 when labeling metastatic melanomas (3). This MART-1 cocktail does not stain […]
