Gross cystic disease fluid is a pathologic secretion from breast composed of several glycoproteins, including GCDFP-15. It is considered to be a marker of apocrine differentiation.15,16 Numerous studies have shown GCDFP-15 (BRST2) to be a specific marker for breast cancer in formalin-fixed paraffinembedded tissues.15,17,18 Other types of tissues that express GCDFP-15 are axillary sweat glands […]
Transducin-like enhancer of split 1 (TLE1) is a member of the TLE family of transcriptional co-repressors that control the transcription of a wide range of genes and has been implicated in embryogenesis, hematopoiesis, and neuronal and terminal epithelial differentiation.15 TLE1 is involved in the Wnt/β-catenin signaling pathway, which is important in synovial sarcomas, and in […]
Probe Enhancer (RNA) is an ancillary reagent that is used as a diluent for RNA targeting probes in an ISH procedure. Probe Enhancer (RNA) facilitates spreading of probes and reduces drying of RNA during hybridization reactions. Effective hybridization may facilitate enhanced staining and reduce artifacts.
Insulinoma-associated protein 1 (INSM1), a zinc-finger transcription factor, is a key regulator of neuroendocrine differentiation during development, and has recently emerged as a reliable immunostaining marker with a nuclear staining pattern for the identification of neuroendocrine and neuroepithelial neoplasms.15,16 Several studies have demonstrated nuclear INSM1 expression in multiple neuroendocrine tumor types, including small cell carcinomas […]
![Tonsil stained with CD54 [E3Q9N] antibody.](https://biocare.net/wp-content/uploads/3296.jpg)
CD54, also known as Intercellular adhesion molecule 1 (ICAM1) is a 90 kDa glycosylated transmembrane protein of the immunoglobulin superfamily. CD54 plays an important role in immunological synapse formation, T-cell activation, leukocyte migration, and numerous cellular immune responses.15 While some studies have shown that CD54 promotes tumor metastasis by regulating various signaling pathways in some […]
![Spleen stained with HLA-B [BC43] antibody](https://biocare.net/wp-content/uploads/3289.jpg)
HLA-B is a highly polymorphic protein encoding gene for the major histocompatibility class I (MHC-I) complex.15 MHC class I molecules are expressed on the cell surface, binding and presenting antigenic peptides to CD8+ T lymphocytes to mediate immune responses against intracellular pathogens and cancers.16 Want to Learn More About HLA-B [BC43] Antibody? Download Our Complimentary […]
![Kaposi sarcoma stained with HHV-8 [13B10] antibody](https://biocare.net/wp-content/uploads/3290.jpg)
Human herpesvirus 8 (HHV-8) also known as Kaposi sarcoma-associated herpesvirus (KSHV), encodes a latent nuclear antigen which is the product of the viral gene ORF73.1 The protein is expressed predominantly during viral latency and appears to play a role in viral integration into the host genome.1 HHV-8 is associated with Kaposi’s sarcoma, primary effusion lymphoma, […]
p27 KIP1 is a member of the Cyclin Inhibitory Protein/Kinase Inhibitory Protein (CIP/KIP) family of cyclin-dependent kinase (Cdk) inhibitors.15 It plays roles in all phases of the cell division cycle. Thus, important cellular functions as the cell division cycle, respiration, RNA processing, translation, and cell adhesion, are under p27 KIP1 regulation.15 Reduced levels of p27 […]
Immunoglobulin lambda light chain mRNA may be detected in normal and neoplastic B-cells in human lymphoid tissue (1-3). Lambda Light Chain Probe is a digoxigenin-conjugated DNA oligonucleotide designed to bind human lambda light chain mRNA.
