Distinguishing between invasive urothelial carcinoma (UC) from other genitourinary malignancies, such as prostatic and renal carcinomas, can be difficult. Several new markers such as GATA binding protein 3 (GATA-3), S100P, and uroplakin III have been developed for this differentiation (1-7). More recently uroplakin II has been introduced (1-7). GATA-3 is a transcription factor and belongs […]
GATA-3 (GATA binding protein 3) is a member of the GATA family of transcription factors. This 50 kDa nuclear protein regulates the development and is expressed in specific cell types within a variety of tissues.1,2 GATA-3 is a zinc finger transcription factor and plays an important role in promoting and directing cell proliferation, development, and […]
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Bladder cancer is the seventh most commonly occurring cancer in the United States with 73,469 new cases reported in 2016 and is associated with high recurrence & progression rates. Bladder cancer is the seventh most commonly occurring cancer in the United States with 73,469 new cases reported in 2016 and is associated with high recurrence […]
Abstract The objective of this study is to examine the efficiency and effectiveness of heat induced epitope retrieval (HIER) when performed on a fully automated instrument using single-sided application of a heating element and topical dispense of retrieval buffer solution, commonly referred to as online retrieval, in comparison to offline HIER via the conventional pressure […]
Biocare Medical takes great pride in our promise of “Fighting Cancer, One Slide at a Time.” Our focus in the fight against cancer is realized through our high-quality immunohistochemistry (IHC) and in situ hybridization (ISH) reagents and instrumentation. Specifically, our sensitive and specific antibodies, molecular probes, and detection chemistries support early and accurate classification of […]
Deciphering the Immune System in Small Intestine: Immune Related Antibodies and Multiplex Strategies for Inflammatory Bowel Disease Multiplex Cocktails for Immunotherapy Targets: PD-L1 with Tumor Specific Transcription Factors Immunohistochemical Double and Triple Stain Strategies with CD8, CD103, FOXP3, PD-1 and CK8/18 in Colon Adenocarcinoma: Quantitation, Prognosis and Immunotherapy
Immunotherapy, also called biologic therapy or biotherapy, is a type of treatment designed to boost the body’s immune system to fight diseases, including cancer. It stimulates and awakens one’s own defense system to improve, target, or restore immune system function. In the last few decades, immunotherapy has become an important part of treating some types […]
Lung cancers are the third most diagnosed cancer in the United States, with about 13.5% of new cancer cases classified as lung, contributing 27.2% of cancer deaths yearly. As of 2011, there were approximately 402,000 people living with lung cancer in the United States. Those diagnosed with lung cancer have a 5 year survival rates […]
