![Breast cancer stained with Epithelial Membrane Antigen (EMA) [E29]](https://biocare.net/wp-content/uploads/3038.jpg)
The Biocare Epithelial Membrane Antigen (EMA) antibody recognizes a heterogeneous family of highly glycosylated transmembrane proteins known as human milk fat globule (HMFG) membrane proteins. Although originally identified in breast tissue, EMA expression is also found in secretory epithelial cells, to a lesser degree in non-secretory epithelium (e.g., squamous epithelium), and rarely in non-epithelial cells.15,18 […]
PSA is a chymotrypsin-like serine protease (kallikrein family) produced by the prostate epithelium.15-17
Leukocyte Common Antigen Antibody recognizes an antigen found on lymphoid cells. It reacts with B cells, T-cell subtypes, monocytes, macrophages, and is weakly expressed with granulocytes. The PD7/26 antibody was included in the 3rd International Workshop. CD45RB reacts with 3 of the 5 glycoproteins in the CD45 family (MW 190, 205 and 220 kDa). It […]
Studies have shown CD45 recognizes an antigen found on lymphoid cells. Most neoplastic B-cells and T-cells stain positively in leukemia and in non Hodgkin’s lymphomas; whereas most neoplastic myeloid and erythroid cells are negative.15-17
Transducin-like enhancer of split 1 (TLE1) is a member of the TLE family of transcriptional co-repressors that control the transcription of a wide range of genes and has been implicated in embryogenesis, hematopoiesis, and neuronal and terminal epithelial differentiation.15 TLE1 is involved in the Wnt/β-catenin signaling pathway, which is important in synovial sarcomas, and in […]
Probe Enhancer (RNA) is an ancillary reagent that is used as a diluent for RNA targeting probes in an ISH procedure. Probe Enhancer (RNA) facilitates spreading of probes and reduces drying of RNA during hybridization reactions. Effective hybridization may facilitate enhanced staining and reduce artifacts.
Insulinoma-associated protein 1 (INSM1), a zinc-finger transcription factor, is a key regulator of neuroendocrine differentiation during development, and has recently emerged as a reliable immunostaining marker with a nuclear staining pattern for the identification of neuroendocrine and neuroepithelial neoplasms.15,16 Several studies have demonstrated nuclear INSM1 expression in multiple neuroendocrine tumor types, including small cell carcinomas […]
![Tonsil stained with CD54 [E3Q9N] antibody.](https://biocare.net/wp-content/uploads/3296.jpg)
CD54, also known as Intercellular adhesion molecule 1 (ICAM1) is a 90 kDa glycosylated transmembrane protein of the immunoglobulin superfamily. CD54 plays an important role in immunological synapse formation, T-cell activation, leukocyte migration, and numerous cellular immune responses.15 While some studies have shown that CD54 promotes tumor metastasis by regulating various signaling pathways in some […]
![Spleen stained with HLA-B [BC43] antibody](https://biocare.net/wp-content/uploads/3289.jpg)
HLA-B is a highly polymorphic protein encoding gene for the major histocompatibility class I (MHC-I) complex.15 MHC class I molecules are expressed on the cell surface, binding and presenting antigenic peptides to CD8+ T lymphocytes to mediate immune responses against intracellular pathogens and cancers.16 Want to Learn More About HLA-B [BC43] Antibody? Download Our Complimentary […]
