E-Cadherin is a transmembrane glycoprotein that plays a key role in cellcell adhesion in epithelial tissues (1-2). The adherens junction between epithelial cells is comprised of extracellular domains of E-Cadherin from adjacent cells, which interact through a molecular zipper motif. In normal tissues, immunostaining of E-Cadherin is localized to the membrane of epithelial cells, consistent […]
Diagnostic reproducibility of lobular vs. ductal lesions, based on histology alone, is less than optimal. The proper distinction between atypical lobular hyperplasia, lobular carcinoma in situ and low-grade ductal carcinoma in situ is critical for patient management. Studies have shown E-cadherin, a negative membrane marker for lobular neoplasia, is useful in the distinction of ductal […]
E-Cadherin, 2X is being discontinued. We will continue to offer these products until 06/30/16 or until current inventory is depleted, whichever occurs first. Biocare does offer E-cadherin (RM), catalog numbers ACI3012, API3012 as a substitute. E-cadherin is a transmembrane glycoprotein that plays a key role in cell-cell adhesion in epithelial tissues (1-2). The adherens junction […]
Immunohistochemical studies have shown E-cadherin antibody to be expressed in breast ductal carcinoma with loss of expression in lobular carcinoma. As a result, mouse monoclonal anti-E-cadherin [HECD-1] has been used by pathologists to differentiate between ductal and lobular carcinomas of the breast, with currently published sensitivity and specificity of approximately 90%. A rabbit monoclonal E-cadherin […]
E-cadherin is a transmembrane glycoprotein that mediates epithelial cell-to cell adhesion. The loss of E-cadherin can result in the disruption of cell clusters.15 It is therefore, postulated that E-cadherin may function as a tumor suppressor protein. The loss of E-cadherin has been associated with metastasis and poor prognosis in invasive breast cancer and can help […]
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Making the distinction between ductal carcinoma in situ (DCIS) and lobular carcinoma (LCIS) can be difficult in some situations. The proper distinction between atypical lobular hyperplasia, lobular carcinoma in situ and low-grade ductal carcinoma in situ is critical for patient management.¹ While histology is the first line of distinction, subsequent immunostains are highly useful. Studies […]
Folate, a B vitamin, is an essential nutrient in the body. Folate is found naturally in foods and can be absorbed through use of a dietary supplement (folic acid). A sufficient intake of folate is needed, as it’s necessary in rapidly proliferating cells for the one-carbon metabolic reaction and DNA biosynthesis, repair and methylation.1 Folate […]
What Tissues Are You Working With? Rodent Tissues Mouse Primary Antibodies Rodent Detection Ordering Information Rat Primary Antibodies Rat-on-Mouse Micro-polymer Detection Use with rat monoclonal antibodies on mouse tissues. The Rat-on-Mouse HRP / AP micro-polymer detection is a two-step system. It is comprised of two reagents: a rat probe that binds to the rat primary […]
