Lung cancer is the leading cause of cancer-related deaths in the United States and worldwide, with non-small cell lung cancer (NSCLC) accounting for 80% of lung cancers.1 NSCLC’s predominate subtypes are adenocarcinomas (ADC) and squamous cell carcinomas (SCC).1 Therapy of NSCLC depends on accurate histological classifications of these two subclassifications.1 Differentiating the two can be […]
13
Mar
Mar
Desmoglein 3 (DSG3) is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily (1,2). Desmogleins exhibit membranous expression and connect with cytokeratins through desmoplakins and plakoglobin. DSG3 is particularly important in the cellular adhesion […]
14
Apr
Apr
Desmoglein 3 (M), 2X is being discontinued. We will continue to offer these products until 06/30/16 or until current inventory is depleted, whichever occurs first. Biocare does offer Desmoglein 3, catalog numbers CM419, PM419 as a substitute. Desmoglein 3 (DSG3) is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein […]
05
Feb
Feb
Desmoglein 3 (DSG3) is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily (1,2). Desmogleins exhibit membranous expression and connect with cytokeratins through desmoplakins and plakoglobin. DSG3 is particularly important in the cellular adhesion […]
17
Sep
Sep
Desmoglein 3 (DSG3) + Napsin A are very sensitive and specific markers, and may be useful for discriminating between lung SqCC and lung adenocarcinoma. DSG3 is a membrane stain that marks lung SqCC while Napsin A is a cytoplasmic stain that marks lung adenocarcinomas. In the vast majority of lung cancers tested, only a single […]
17
Sep
Sep
Desmoglin 3 (DSG3) is often highly expressed in various squamous cell carcinomas (SqCC). In studies of lung SqCC, DSG3 has demonstrated a sensitivity of 85-99% and an ability to discriminate lung adenocarcinoma with a specificity of 98-100%. Numerous studies have shown CK5/6 to be a sensitive marker for lung SqCC. Two sudies using a cocktail […]
16
Sep
Sep
Desmoglein 3 (DSG3) is a type of desmosomal cadherin, thought to mediate calcium dependent cell-cell adhesion as part of a larger structure found in epithelia and cardiac muscle called a desmosome.15
12
Dec
Dec
Transducin-like enhancer of split 1 (TLE1) is a member of the TLE family of transcriptional co-repressors that control the transcription of a wide range of genes and has been implicated in embryogenesis, hematopoiesis, and neuronal and terminal epithelial differentiation.15 TLE1 is involved in the Wnt/β-catenin signaling pathway, which is important in synovial sarcomas, and in […]
26
Mar
Mar
Hematoxylin is used as a nuclear dye, staining the nuclei blue/black and providing good detail of the cell and tissue section structures. This provides good contrast of the microscopic slides and facilitates their observation.
![Tonsil stained with CD54 [E3Q9N] antibody.](https://biocare.net/wp-content/uploads/3296.jpg)
22
Mar
Mar
CD54, also known as Intercellular adhesion molecule 1 (ICAM1) is a 90 kDa glycosylated transmembrane protein of the immunoglobulin superfamily. CD54 plays an important role in immunological synapse formation, T-cell activation, leukocyte migration, and numerous cellular immune responses.15 While some studies have shown that CD54 promotes tumor metastasis by regulating various signaling pathways in some […]
