Clone 5D3 recognizes cytokeratin (CK) 8 and 18 intermediate filament proteins. These are 52.5 kDa and 45 kDa respectively. In normal tissues, 5D3 recognizes all simple and glandular epithelium.15-16 In neoplastic tissues, 5D3 may prove useful for the identification of adenocarcinomas and some squamous cell carcinomas.15 Use in conjunction with HMW CK to rule out […]
![Colon cancer stained with Pan Cytokeratin [Lu-5] antibody](https://biocare.net/wp-content/uploads/lw.jpg)
Pan Cytokeratin [Lu-5] antibody is has been demonstrated as a useful marker for the differentiation of epithelial and mesothelial cells from mesenchymal cells in normal and tumor tissues. It has been shown to serve as a first-order pan cytokeratin antibody for both acidic (type I) and basic (type II) cytokeratin subfamilies of all vertebrates tested […]
![Colon cancer stained with Pan Cytokeratin [AE1/AE3] antibody.](https://biocare.net/wp-content/uploads/011-2.jpg)
AE1/AE3 recognizes the acidic and basic (Type I and II) subfamilies of cytokeratins. The cocktail of these two antibodies can be used to detect most human epithelia. The acidic cytokeratins have molecular weights of 56.5, 55, 51, 50, 50, 48, 46, 45, and 40 kDa. The basic cytokeratins have molecular weights of 65-67, 64, 59, […]
Pan Cytokeratin antibody Plus is a combination of [AE1/AE3] and Cytokeratin (CK) 8/18 [5D3] and can be used to detect most human epithelia. [AE1/AE3] recognizes acidic and basic subfamilies of cytokeratins, with molecular weights ranging from 40 to 67 kDa. CK8/18 [5D3] recognizes Cytokeratin 8 and 18 intermediate filament proteins. In normal tissues, [5D3] recognizes […]
Cytokeratin 5/14 Cocktail, 2X is being discontinued. We will continue to offer these products until 06/30/16 or until current inventory is depleted, whichever occurs first. Biocare does offer Cytokeratin 5/14 Cocktail, catalog numbers ACI3025 & API3025 as a substitute. CK5 [XM26] has been shown to have positive reactivity for CK5 protein and lack of reactivity […]
CK5 is distributed in many non-keratinizing stratified squamous epithelia such as tongue mucosa, basal epithelia, hair follicles, trachea, as well as basal cells in prostate glands and myoepithelial cells in mammary glands.15-19 CK5 is also expressed in most epithelial and biphasic mesotheliomas. CK5 has also been noted in large cell carcinomas and pulmonary squamous cell […]
Cytokeratin 19 antibody reacts with the rod domain of human keratin 19, a 40kDa polypeptide. The antibody reacts with MCF-7 cells and has been shown to label trichoblastoma, thyroid tumors, oral cancer, and epithelial odontogenic tumors. CK19 is not expressed in most hepatocytes, therefore cytokeratin 19 is useful in the identification of liver metastasis and […]
Cytokeratin 18 (CK18) is a 45 kDa acidic intermediate filament protein. It is normally coexpressed with cytokeratin 8 and is found in most simple ductal and glandular epithelia.15 The antibody reacts with a wide variety of neoplastic tissues such as gastrointestinal tract, lung, and breast tumors;16-18 whereas tumor cells of nonepithelial origin such as glioma, […]
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Biocare Medical takes great pride in our promise of “Fighting Cancer, One Slide at a Time.” Our focus in the fight against cancer is realized through our high-quality immunohistochemistry (IHC) and in situ hybridization (ISH) reagents and instrumentation. Specifically, our sensitive and specific antibodies, molecular probes, and detection chemistries support early and accurate classification of […]
