The Cytokeratin 5 (CK5) (R) [EP42] antibody is a rabbit monoclonal antibody raised for the detection of cytokeratin 5, a type II intermediate filament protein. CK5 is expressed in the active basal layers of most stratified squamous epithelia.15 CK5 has been identified as a specific immunohistochemical marker for lung squamous cell carcinoma (SqCC), with minimal […]
MACH Infinity 2.5 is designed using a one-step method for detecting mouse and rabbit primary antibodies to form an antibody-enzyme complex. This complex is then visualized using an appropriate substrate/chromogen. In the one-step method a secondary antibody directly linked to the micro-polymer is applied.
![Tonsil stained with CD54 [E3Q9N] antibody.](https://biocare.net/wp-content/uploads/3296.jpg)
CD54, also known as Intercellular adhesion molecule 1 (ICAM1) is a 90 kDa glycosylated transmembrane protein of the immunoglobulin superfamily. CD54 plays an important role in immunological synapse formation, T-cell activation, leukocyte migration, and numerous cellular immune responses.15 While some studies have shown that CD54 promotes tumor metastasis by regulating various signaling pathways in some […]
![H pylori infected stomach tissue (HPY19) stained with Helicobacter pylori [EPR10353] antibody](https://biocare.net/wp-content/uploads/3291-1.jpg)
Helicobacter pylori is a spiral-shaped, gram-negative bacterium, which colonizes the gastric epithelium.1 Want to Learn More About Helicobacter pylori Antibody? Download Our Complimentary White Paper!
5p15.2 Red FISH Probe is intended to hybridize to the 5p15.2 region on chromosome 5. The clinical interpretation of any positive or negative hybridization events should be complemented by the use of appropriate controls and other diagnostic tests where appropriate. Evaluation should be carried out within the context of the patient’s clinical history by a […]
5p15.2 Red FISH Probe is designed to hybridize to the 5p15.2 region located on chromosome 5. The clinical interpretation of any positive or negative hybridization events should be complemented by the use of appropriate controls and other diagnostic tests where appropriate. Evaluation should be carried out within the context of the patient’s clinical history by […]
![Tonsil stained with VISTA [BLR035F] antibody](https://biocare.net/wp-content/uploads/3271-1.jpg)
V-domain Ig-containing suppressor of T cell activation (VISTA), also known as PD-1H, is a member of the immunoglobulin (Ig) superfamily, whose extracellular domain bears homology to the B7 family ligand, particularly PDL1. VISTA is predominantly expressed on granulocytic, myeloid cells and T cells.15 VISTA expresses on T cells as a part of an inhibitory immune […]
The p53 tumor suppressor protein is encoded by the TP53 gene located on chromosome 17p13. Under normal conditions the TP53 gene functions as a safeguard in maintaining cellular homeostasis (1). Furthermore, the TP53 gene regulates suppressive mechanisms that mediate cell cycle arrest, senescence and apoptosis (1). Chromosomal abnormalities involving the TP53 gene are associated with […]
![Tonsil stained with HLA-DR [TAL 1B5] antibody](https://biocare.net/wp-content/uploads/3273.jpg)
HLA-DR (Human Leukocyte Antigen – DR isotype) is a major histocompatibility complex (MHC) class II antigen presentation molecule, critical for the activation of lymphocytes and the coordinating of adaptive immune responses. HLA DR antigen is required for tumor-associated antigen recognition by CD4+ T cells. It is normally expressed on antigen-presenting cells including monocytes, macrophages, dendritic […]
![Spleen stained with Glycophorin A [JC159] antibody](https://biocare.net/wp-content/uploads/3272.jpg)
Glycophorin A, which is the major membrane sialoglycoprotein of human red cells and their precursors, is a specific and early marker for the normal erythroid lineage.15 Glycophorin A is expressed at all stages of erythroid differentiation that includes both nucleated and non-nucleated stages of differentiation. Glycophorin A is a very important diagnostic marker of acute […]
