CK5 is distributed in many non-keratinizing stratified squamous epithelia such as tongue mucosa, basal epithelia, hair follicles, trachea, as well as basal cells in prostate glands and myoepithelial cells in mammary glands.15-19 CK5 is also expressed in most epithelial and biphasic mesotheliomas. CK5 has also been noted in large cell carcinomas and pulmonary squamous cell […]
Breast Cocktail (CK HMW/p63 + CK7/8/18) is comprised of mouse monoclonal anti-CK HMW and anti-p63 antibodies as well as rabbit monoclonal anti-CK7 and mouse monoclonal anti-CK8/18 antibodies. CK HMW (high molecular weight cytokeratin) is expressed in the cytoplasm of basal cells and myoepithelium of breast tissue (1-4). p63 is a transcription factor present in the […]
CK5 and CK14 are high molecular weight cytokeratins expressed in a variety of normal and neoplastic epithelial tissues (1). In prostate tissue, mRNA for CK5 and CK14 has been detected in the basal cells of normal glands and prostatic intraepithelial neoplasia (PIN), a precursor lesion to prostatic adenocarcinoma; however, expression of CK5 or CK14 was […]
Concord, CA, July 17, 2014 – Biocare Medical is proud to announce that the United States Patent and Trademark Office has issued US Patent 8,603,765 to Biocare Medical for its PIN-4™ (CK5/14 + P63 + P504S) Multiplex immunohistochemistry (IHC) technology. The PIN-4 antibody cocktail of P504S + p63 + High Molecular Weight Cytokeratin permits the […]
CK5/14, 3X (Breast) is being discontinued. We will continue to offer these products until 06/30/16 or until current inventory is depleted, whichever occurs first. Biocare does offer Cytokeratin 5/14 Cocktail, catalog numbers ACI3025, API3025 as a substitute. CK5/14, 3X antibody (Breast) [XM26 and LL002] is comprised of mouse monoclonal anti-CK5 and anti-CK14 antibodies. CK5 and […]
CK5 and CK14 are high molecular weight cytokeratins expressed in a variety of normal and neoplastic epithelial tissues. p63, a homolog of the tumor suppressor p53, was detected in nuclei of the basal epithelium in normal prostate glands; however, it was not expressed in malignant tumors of the prostate. Expression of P504S protein is found […]
In normal epithelia, HMW Cytokeratins (CK5 and CK14) stain basal epithelia in the prostate gland.p63 is detected in prostate basal epithelial nuclei in normal prostate, however, is negative in malignant tumors of the prostate gland. Thus p63 is useful as a differential marker for benign and malignant tumors of the prostate gland and can be […]
MART-1 recognizes a protein of 18 kDa, identified at MART-1 (Melanoma Antigen Recognized by T cells).1 MART-1 is a useful addition to melanoma panels as it is apparently specific for melanocytic lesions.1,2 Studies have shown that MART-1 is more sensitive than HMB45 when labeling metastatic melanomas.3 This MART-1 cocktail does not stain steroid tumors. Tyrosinase […]
![Colon cancer stained with Pan Cytokeratin [Lu-5] antibody](https://biocare.net/wp-content/uploads/lw.jpg)
Pan Cytokeratin [Lu-5] antibody is has been demonstrated as a useful marker for the differentiation of epithelial and mesothelial cells from mesenchymal cells in normal and tumor tissues. It has been shown to serve as a first-order pan cytokeratin antibody for both acidic (type I) and basic (type II) cytokeratin subfamilies of all vertebrates tested […]
![Colon cancer stained with Pan Cytokeratin [AE1/AE3] antibody.](https://biocare.net/wp-content/uploads/011-2.jpg)
AE1/AE3 recognizes the acidic and basic (Type I and II) subfamilies of cytokeratins. The cocktail of these two antibodies can be used to detect most human epithelia. The acidic cytokeratins have molecular weights of 56.5, 55, 51, 50, 50, 48, 46, 45, and 40 kDa. The basic cytokeratins have molecular weights of 65-67, 64, 59, […]
