Cytokeratin 18 (CK18) is a 45 kDa acidic intermediate filament protein. It is normally coexpressed with cytokeratin 8 and is found in most simple ductal and glandular epithelia.15 The antibody reacts with a wide variety of neoplastic tissues such as gastrointestinal tract, lung, and breast tumors;16-18 whereas tumor cells of nonepithelial origin such as glioma, […]
Empire Genomics’ HPV Type 18 Probe is a digoxigenin labeled cDNA probe designed to hybridize HPV Type 18 E6/E7 sequences.
![Loss of SMAD4 [EP618Y] antibody on pancreatic cancer tissue](https://biocare.net/wp-content/uploads/3242.jpg)
SMAD4 is a DNA-binding protein that belongs to the SMAD family of transcription factors. Activated SMAD4 complexes accumulate in the nucleus and act as mediators of TGF-β signal transduction (1,2). SMAD4 mutations or deletions are linked to hereditary hemorrhagic telangiectasia syndrome, and juvenile polyposis syndrome (1). SMAD4 mutations or deletions have also been implicated in […]
![Breast cancer stained with BCA-225 [Cu-18] antibody](https://biocare.net/wp-content/uploads/3241-1.jpg)
BCA-225 (Breast Cancer Antigen 225) is a 225 kD glycoprotein present in human breast carcinoma cells, as well as adenocarcinomas of the breast, kidney, ovary, and lung (1,2). Antibody clone Cu-18 was identified as specifically recognizing BCA-225 in breast carcinomas, in both the primary tumor and its metastatic derivatives (3,4). BCA-225 is considered to be […]
Breast Cocktail (CK HMW/p63 + CK7/8/18) is comprised of mouse monoclonal anti-CK HMW and anti-p63 antibodies as well as rabbit monoclonal anti-CK7 and mouse monoclonal anti-CK8/18 antibodies. CK HMW (high molecular weight cytokeratin) is expressed in the cytoplasm of basal cells and myoepithelium of breast tissue (1-4). p63 is a transcription factor present in the […]
The Ki-67 nuclear antigen is associated with cell proliferation and found throughout the cell cycle; though not in G0 phase (1,2). The assessment of Ki-67 proliferation in breast cancers has shown the Ki-67 labelling index is an important predictor of survival (3). Cytokeratin (CK) 7 is expressed in epithelial cells of the ovary, lung and […]
Gene rearrangement in t(14;18)/IGH-MALT1 was detected in MALT lymphoma first. The frequencies at which the translocation occurs vary markedly with the primary site of the disease1. IGH-MALT1 rearrangements were described also in other B-NHLs such as DLBCL (Diffuse Large B-Cell Lymphoma)2. IGH-MALT1 fusion in the t(14;18)(q32;q21) have been identified in marginal zone B-cell lymphomas of […]
Clones EP17 and EP30 recognize cytokeratins (CK) 8 and 18, both of which are low molecular weight intermediate filament proteins (52.5 kDa and 45 kDa respectively). In normal tissues, CK8/18 recognizes all simple and glandular epithelium (1). In neoplastic tissues, CK8/18 may prove useful for the identification of most adenocarcinomas and some squamous cell carcinomas. […]
CK7/18, 3X (Breast) is being discontinued. We will continue to offer these products until 06/30/16 or until current inventory is depleted, whichever occurs first. Biocare does offer CK7 and CK18, catalog numbers CRM339, PRM339, IP339 and ACI3061, API3061 as a substitute. CK7/18, 3X (Breast) [BC1 and E431-1] is comprised of rabbit monoclonal anti-CK7 and anti-CK18 […]
![Colon cancer stained with Pan Cytokeratin [Lu-5] antibody](https://biocare.net/wp-content/uploads/lw.jpg)
Pan Cytokeratin [Lu-5] antibody is has been demonstrated as a useful marker for the differentiation of epithelial and mesothelial cells from mesenchymal cells in normal and tumor tissues. It has been shown to serve as a first-order pan cytokeratin antibody for both acidic (type I) and basic (type II) cytokeratin subfamilies of all vertebrates tested […]
