This antibody recognizes a protein of 68-75 kDa, identified as Chromogranin A (a protein of 439-amino acid which is encoded on chromosome 14). Although the epitopes for [LK2H10] and [PHE5] are not precisely mapped, experimental data suggests that they are different. A cocktail of LK2H10 and PHE5 is specifically designed for sensitive detection of Chromogranin […]
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What Tissues Are You Working With?
Lung cancers are the third most diagnosed cancer in the United States, with about 13.5% of new cancer cases classified as lung, contributing 27.2% of cancer deaths yearly. As of 2011, there were approximately 402,000 people living with lung cancer in the United States. Those diagnosed with lung cancer have a 5 year survival rates […]
Achaete-scute complex homolog-1 (ASCL1), known as mASH1 in rodents and hASH1 in humans, is a basic helix-loop-helix transcription factor that is critical for neuroendocrine cell differentiation (1,2). Neuroendocrine carcinomas can arise in different sites such as lung, the gastrointestinal tract, prostate and skin (2). High grade, poorly differentiated neuroendocrine carcinomas are classified as neuroendocrine carcinomas […]
This monoclonal antibody [clone 27G12] is a reliable marker for neuroendocrine and neuronal neoplasms, as well as their normal counterparts.15,16 Studies have shown synaptophysin has a higher degree of specificity than NSE, but is often used in conjunction with CD56, NSE and chromogranin. This clone aids in providing sharper staining when compared to other rabbit […]
