CK5 and CK14 are high molecular weight keratins expressed in the cytoplasm of basal cells and myoepithelium of breast tissue.15 p63 is a transcription factor present in the nuclei of myoepithelial cells.16 P504S is a peroxisomal and mitochondrial enzyme that plays a role in bile acid synthesis and β-oxidation of branched chain fatty acids.17
Concord, CA, July 17, 2014 – Biocare Medical is proud to announce that the United States Patent and Trademark Office has issued US Patent 8,603,765 to Biocare Medical for its PIN-4™ (CK5/14 + P63 + P504S) Multiplex immunohistochemistry (IHC) technology. The PIN-4 antibody cocktail of P504S + p63 + High Molecular Weight Cytokeratin permits the […]
CK5 and CK14 are high molecular weight cytokeratins expressed in a variety of normal and neoplastic epithelial tissues. p63, a homolog of the tumor suppressor p53, was detected in nuclei of the basal epithelium in normal prostate glands; however, it was not expressed in malignant tumors of the prostate. Expression of P504S protein is found […]
CK5 and CK14 are high molecular weight keratins expressed in the cytoplasm of basal cells and myoepithelium of breast tissue.15 p63 is a transcription factor present in the nuclei of myoepithelial cells.16 P504S is a peroxisomal and mitochondrial enzyme that plays a role in bile acid synthesis and β-oxidation of branched chain fatty acids.17
P504S, also known as α-Methylacyl coenzyme A racemase (AMACR), is a peroxisomal and mitochondrial enzyme that plays a role in bile acid synthesis and β-oxidation of branched chain fatty acids (1). AMACR was initially identified from a cDNA library as a gene that is over-expressed in human prostate cancer; with little or no expression in […]
Breast Cocktail (CK HMW/p63 + CK7/8/18) is comprised of mouse monoclonal anti-CK HMW and anti-p63 antibodies as well as rabbit monoclonal anti-CK7 and mouse monoclonal anti-CK8/18 antibodies. CK HMW (high molecular weight cytokeratin) is expressed in the cytoplasm of basal cells and myoepithelium of breast tissue (1-4). p63 is a transcription factor present in the […]
CK5 and CK14 are high molecular weight cytokeratins expressed in a variety of normal and neoplastic epithelial tissues (1). In prostate tissue, mRNA for CK5 and CK14 has been detected in the basal cells of normal glands and prostatic intraepithelial neoplasia (PIN), a precursor lesion to prostatic adenocarcinoma; however, expression of CK5 or CK14 was […]
High molecular weight cytokeratins are expressed in a variety of normal and neoplastic epithelial tissues.15 p63, a homolog of the tumor suppressor p53, has been identified in proliferating basal cells in the epithelial layers of a variety of tissues, including epidermis, cervix, urothelium and prostate.16 αMethylacyl coenzyme A racemase (AMACR), also known as P504S, is […]
High molecular weight cytokeratins are expressed in a variety of normal and neoplastic epithelial tissues (1). In prostate, CK HMW [34βE12] has been shown to be a useful marker of basal cells of normal glands and prostatic intraepithelial neoplasia (PIN), a precursor lesion to prostatic adenocarcinoma; whereas invasive prostatic adenocarcinoma typically lacks a basal cell […]
High molecular weight cytokeratins are expressed in a variety of normal and neoplastic epithelial tissues (1). In prostate, CK HMW [34βE12] has been shown to be a useful marker of basal cells of normal glands and prostatic intraepithelial neoplasia (PIN), a precursor lesion to prostatic adenocarcinoma; whereas invasive prostatic adenocarcinoma typically lacks a basal cell […]
