The Biocare CDX2 antibody detects CDX2, a homeobox gene–encoded, intestine-specific transcription factor.15 CDX2 is useful in establishing the gastrointestinal origin of metastatic adenocarcinomas and carcinoids and can aid in distinguishing metastatic colorectal adenocarcinoma from tumors of unknown origin.15-21 Studies have shown that CDX2 to be more specific and sensitive than villin or CK20.15,19,20 CDX2 expression […]
CDX2 is a homeobox gene that encodes an intestine-specific transcription factor (1). CDX2 has been useful to establish gastrointestinal origin of metastatic adenocarcinomas and carcinoids and can be especially useful in distinguishing metastatic colorectal adenocarcinoma from tumors of unknown origin (1-7). CDX2 has been shown to be more specific and more sensitive than villin or […]
CDX2 is a homeobox gene that encodes an intestine-specific transcription factor and is expressed in the nuclei of epithelial cells of the intestine, from duodenum to rectum. The CDX2 protein is expressed in primary and metastatic colorectal carcinomas (1,2). It has also been identified in primary ovarian mucinous tumors and metastatic mucinous carcinomas involving the […]
Approximately 150,000 men and women in the United States are diagnosed with colorectal cancer annually, leading to an annual estimated 51,000 deaths.1 Colorectal cancers are the third-most common in the United States (excluding skin cancer), with about 8.1% of new cancer cases diagnosed, contributing to approximately 8.3% of cancer deaths yearly.1 Worldwide, colorectal cancers are […]
Approximately 12,000 men and women in the United States are diagnosed with gallbladder cancer annually, leading to an annual estimated 4,000 deaths.1 Gallbladder and other biliary cancers are comparatively rare in the United States, with about 0.7% of new cancer cases classified as gallbladder, contributing approximately 0.6% of cancer deaths yearly.1 Worldwide, gallbladder and other […]
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What Tissues Are You Working With?
Biocare Medical takes great pride in our promise of “Fighting Cancer, One Slide at a Time.” Our focus in the fight against cancer is realized through our high-quality immunohistochemistry (IHC) and in situ hybridization (ISH) reagents and instrumentation. Specifically, our sensitive and specific antibodies, molecular probes, and detection chemistries support early and accurate classification of […]
