CD79a antibody is an intracellular component of the signal transduction pathway of the B-cell Receptor, appearing at pre-B-cell stage and persisting until the plasma cell stage. Studies have shown that CD79a is found in a majority of acute leukemia of precursor-B-cell-type as well as B-cell neoplasms, B-cell lymphomas and some myelomas. It is not present […]
What Tissues Are You Working With?
Nuclear Decloaker is a Tris buffer heat retrieval solution, pH 9.5. It is specially designed for nuclear antigens including ER, PR, Ki-67, p53, cyclin D1, TdT and TTF-1. Other antibodies that show improved staining include ALK1, ALKc, bcl-2, CA125, CD3 (M), CD15, CD30, CD31, CD79a, MART-1, Tyrosinase and Villin. Nuclear Decloaker can be used with […]
EDTA Decloaker is a heat retrieval solution, pH 8.4-8.7. Recommended for use with antibodies with low antigen expression (cyclin D1, CD1a, CD3, CD4, CD8, CD23, bcl-6, CD61, CD79a and TdT). EDTA Decloaker is a potent agent for epitope retrieval and tissues may be 5-10 times more sensitive to immunohistochemical staining. EDTA Decloaker can be used […]
Oct-2 is a transcription factor that binds to the immunoglobin gene octamer sites regulating B-cell specific genes. Oct-2 antibody protein expression is seen in germinal center B-cells and is greater in germinal center derived B-cell lymphomas. Studies suggest that morphologic and immunohistochemical studies can distinguish most cases of classic Hodgkin’s lymphoma (CHL) from its imitators. […]
BOB-1 antibody is a B-lymphocyte-specific transcriptional co-activator for Oct-1 and Oct-2 transcription factors. BOB-1 and Oct-2 are useful for the B-lineage determination of CD20-plasmablastic or primary effusion subtypes of diffuse large B-cell lymphoma (DLBCL). Other studies have shown BOB-1, CD79a and Cyclin E are useful markers for discriminating classical Hodgkin’s lymphoma from primary mediastinal large […]
