CD30 Ki-1 antibody is expressed in mononuclear Hodgkin’s and multinucleated Reed-Sternberg cells in Hodgkin’s disease, in tumor cells of a majority of anaplastic large cell lymphomas, in a varying proportion of activated T and B cells, and by embryonal carcinomas. It aids in distinguishing large cell lymphomas derived from activated lymphoid cells, from histiocytic malignancies […]
Biocare Medical takes great pride in our promise of “Fighting Cancer, One Slide at a Time.” Our focus in the fight against cancer is realized through our high-quality immunohistochemistry (IHC) and in situ hybridization (ISH) reagents and instrumentation. Specifically, our sensitive and specific antibodies, molecular probes, and detection chemistries support early and accurate classification of […]
CD3 is expressed throughout the T-cell differentiation process. CD3 is a highly specific and sensitive T-cell lineage marker, making it ideal for the immunophenotypic analysis of lymphohaematopoietic malignancies. Notable exceptions include some of the more aggressive large T-cell lymphomas and CD30 (Ki-1) positive anaplastic large cell lymphomas, which may not express detectable antigen.15-17 CD3 [LN10] […]
The OX40 receptor, also known as CD134, is a tumor necrosis superfamily receptor (TNSFR4) that is recognized as a costimulatory receptor for T cells. OX40 is predominantly expressed on activated CD4 T cells. OX40 has been shown to be essential for the regulation, differentiation, and survival of conventional CD4 and CD8 T cells.1 Multiple studies […]
Cytotoxic lymphocytes, including NK cells and cytotoxic T lymphocytes (CTLs), play a major role in the defense against neoplastic processes and viral infections (1). Granule exocytosis is the mechanism by which cytotoxic lymphocytes may induce lysis of its target. This involves granule-associated cytotoxic proteins, including the T-cell intracellular antigen-1 (TIA-1), perforin and granzyme B (1,2). […]
![Breast cancer stained with Epithelial Membrane Antigen (EMA) [E29]](https://biocare.net/wp-content/uploads/3038.jpg)
The Biocare Epithelial Membrane Antigen (EMA) antibody recognizes a heterogeneous family of highly glycosylated transmembrane proteins known as human milk fat globule (HMFG) membrane proteins. Although originally identified in breast tissue, EMA expression is also found in secretory epithelial cells, to a lesser degree in non-secretory epithelium (e.g., squamous epithelium), and rarely in non-epithelial cells.15,18 […]
