CD39, also known as ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1), can hydrolyze extracellular ATP and ADP. It is one of the key enzymes in the adenosine pathway and targeted adenosine may play a role in antitumor strategies.15 CD39 pathway inhibits natural killer (NK) cells and promotes the metastasis of tumors.15 Overexpression of CD39 has been observed […]
![Spleen stained with CD3 [BC33]](https://biocare.net/wp-content/uploads/3170_CD3BC33-in-Spleen-10X.jpg)
Monoclonal antibody to human CD3, when used in conjunction with other antibodies, is regarded as a reliable pan T-cell antibody used in the immunophenotyping of lymphomas in paraffin sections. Most T-cell lymphomas show positivity for CD3. Notable exceptions include some of the more aggressive large T-cell lymphomas and anaplastic large cell (Ki-1, CD30) lymphomas, which […]
CD3 is expressed throughout the T-cell differentiation process. CD3 is a highly specific and sensitive T-cell lineage marker, making it ideal for the immunophenotypic analysis of lymphohaematopoietic malignancies. Notable exceptions include some of the more aggressive large T-cell lymphomas and CD30 (Ki-1) positive anaplastic large cell lymphomas, which may not express detectable antigen.15-17 CD3 [LN10] […]
The Biocare CD33 antibody detects CD33 (Siglec-3), a 67 kDa glycosylated transmembrane receptor expressed on myeloid-specific cells.15, 16 Historically, CD33 was primarily used for flow cytometry; more recently, a paraffin embedded tissue–compatible CD33 antibody has been developed. CD33 is useful for phenotyping acute myelogenous leukemias, with immunohistochemical (IHC) analysis providing results equivalent to flow cytometry.15, […]
Pan Lymphoma Cocktail (LCA + CD20 + CD3 + CD43) are specific leukocyte markers used in the identification and assessment of lymphoid neoplasms. This combination of antibodies offers a marker for the identification of a variety of leukocytes. CD45 also known as leucocyte common antigen (LCA), is expressed on hematopoietic cell lines, but absent on […]
CD31 recognizes a 100kDA glycoprotein in endothelial cells and 130kD in platelets. It reacts weakly with mantle zone B-cells, peripheral T-cells, and neutrophils.15 CD31 can detect vascular endothelium associated antigen and has been used as a marker for benign and malignant human vascular disorders, myeloid leukemia infiltrates and megakaryocytes in normal bone marrow.15-17 CD31 can […]
![Liver cancer stained with CD47 [EPR21794] antibody](https://biocare.net/wp-content/uploads/3284.jpg)
CD47 has been shown to have a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins.15 In the brain, it appears to play an important role in memory formation and synaptic plasticity in the hippocampus.16 CD47 is a receptor for SIRPA, binding to […]
