CD20 [L26] reacts with a protein of a 30-33 kDa polypeptide present in Bcells. L26 reacts with the majority of B-cells present in peripheral blood and lymphoid tissues.15-17 In normal lymphoid tissue, L26 marks B-cells in germinal centers, particularly immunoblasts. This antibody has been shown to be a reliable marker as a pan B-cell marker. […]
![Tonsil stained with CD20 [BC30] antibody](https://biocare.net/wp-content/uploads/3287.jpg)
CD20 is a B-lymphocyte antigen, composed of an activated-glycosylated phosphoprotein which is expressed on the surface of all B-cells.15 CD20 is involved in the regulation of trans-membrane Ca2+ conductance and plays critical roles in cell‐cycle progression during human B cell proliferation and activation.15 CD20 is expressed on more than 90% of B-cell lymphoma cells making […]
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Biocare Medical takes great pride in our promise of “Fighting Cancer, One Slide at a Time.” Our focus in the fight against cancer is realized through our high-quality immunohistochemistry (IHC) and in situ hybridization (ISH) reagents and instrumentation. Specifically, our sensitive and specific antibodies, molecular probes, and detection chemistries support early and accurate classification of […]
Detection of abnormal numbers and/or distribution of bone marrow (BM) plasma cells (PCs) on trephine biopsies can be of importance in the differential diagnosis of multiple myeloma (MM) and other PC neoplasms (1,2). CD138 expression in hematologic malignancy in bone marrow biopsy specimens is limited to nonneoplastic and neoplastic plasma cells and lymphoplasmacytic lymphoma in […]
Oct-2 is a transcription factor that binds to the immunoglobin gene octamer sites regulating B-cell specific genes. Oct-2 antibody protein expression is seen in germinal center B-cells and is greater in germinal center derived B-cell lymphomas. Studies suggest that morphologic and immunohistochemical studies can distinguish most cases of classic Hodgkin’s lymphoma (CHL) from its imitators. […]
