Detection of abnormal numbers and/or distribution of bone marrow (BM) plasma cells (PCs) on trephine biopsies can be of importance in the differential diagnosis of multiple myeloma (MM) and other PC neoplasms (1,2). CD138 expression in hematologic malignancy in bone marrow biopsy specimens is limited to nonneoplastic and neoplastic plasma cells and lymphoplasmacytic lymphoma in […]
CD138/syndecan-1 is an excellent marker for identifying plasma cells, as CD138 is a transmembrane heparin proteoglycan present on the surface membrane of plasma cells that remains active in formalin-fixed paraffin-embedded bone marrow sections. Other hematopoietic cells, endothelial cells and lymphoplasmacytoid lymphomas in bone marrow are CD138 negative (1). CD138 is also expressed in fibroblasts, keratinocytes […]
CD138 / syndecan-1 protein backbone is a single chain molecule of 30.5 kDa. Five putative GAG attachment sites exist in the extracellular domain. GAG fine structure appears to reflect the cellular source of the syndecan. Expression of CD138 in human hematopoietic cells is restricted to plasma cells in normal bone marrow. Early B-cell precursors in […]
Biocare Medical takes great pride in our promise of “Fighting Cancer, One Slide at a Time.” Our focus in the fight against cancer is realized through our high-quality immunohistochemistry (IHC) and in situ hybridization (ISH) reagents and instrumentation. Specifically, our sensitive and specific antibodies, molecular probes, and detection chemistries support early and accurate classification of […]
Immunoglobulin G (IgG) is an antibody isotype secreted by plasma cells and composed of four peptide chains – two identical heavy chains and two identical light chains arranged in a Y-shape typical of antibody monomers (1). In humans, IgG consists of four subclasses that differ only marginally in their amino acid composition (1). Representing approximately […]
