Oncore™

System Overview

The ONCORE Automated Slide Staining System performs IHC while enabling customized processing of up to 36 slides at once. Each slide loaded onto the ONCORE system may be processed with a different protocol; regardless of position. Slide processing is facilitated by unique reaction modules that enclose slides between a heated platform and a novel reagent containment chamber. In this compact and convenient bench-top system, reagents are dispensed onto slides through ports attached to each chamber. To maximize stain intensity and minimize background, chambers are capable of gentle agitation to enhance processing throughout the staining procedure. A full range of specially designed reagents to support IHC are available for the ONCORE system.

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ONCORE Video Presentation


Full Automation

The ONCORE Automated Slide Staining System is a compact and convenient bench-top instrument that is capable of performing immunohistochemistry (IHC) procedures on formalin-fixed paraffin-embedded (FFPE) tissues. The on-board capabilities include slide baking, deparaffinization, antigen retrieval, and antibody or probe detection for IHC and Multiplex IHC applications.

  • Performs on-line protocol steps
  • Baking to chromogen incubation for improved consistency
  • Capable of processing IHC procedures
  • Small footprint conserves bench space

Innovative Technology

The ONCORE’s unique reaction modules enclose slides between a heated platform and a reagent containment chamber. These chambers provide gentle agitation during reagent incubation to maximize stain intensity. Reagent vials are identified using RFID technology which stores vital information including name, lot number, expiration date, and the number of tests. This minimizes user error through real-time tracking of reagent volumes and enables sharing of reagents among multiple instruments.

  • Kinetic incubation to maximize staining intensity
  • Unique RFID reagent tracking technology
  • Capable of processing IHC procedures
  • Reagent chambers minimize reagent use & evaporation

Convenience & Ease-of-use

The ONCORE contains multiple features for added convenience, flexibility, and ease of use. The system’s software interface is intuitive and easy to use; requiring minimal user interaction from the beginning-to-end of a run. The ONCORE also utilizes 2-D Matrix labels that can be printed for patient slides in order to eliminate patient identification errors. The independent slide positions allow for unique protocols to be performed on each slide during a run.

  • Intuitive software for improved ease of use
  • 2-D Matrix labels to virtually eliminate patient ID errors
  • Waste separation reduces hazardous waste disposal costs

Reagent Menu

IHC reagents specifically designed for use on the instrument produce exceptional staining quality. Use primary antibodies from alternate vendors using the 7 ml Improv™ vials. The ONCORE’s Multiplex IHC capability and patent-pending Multiplex detection conserves patient tissue, reduces slide volume and can lower labor costs by 50%.

  • Pre-optimized ONCORE IHC reagent line
  • User-fillable vials for third party primary antibodies
  • Simultaneous Multiplex IHC*

Note:  The ONCORE is available for sale in North America, Central America, South America, India, Indonesia, Turkey and Japan.

ONCORE Detection

ONCORE Detection is available for either single or double stains as part of an IHC staining procedure on the ONCORE Automated Slide Stainer. The HRP (horseradish peroxidase) or AP (alkaline phosphatase) enzyme-antibody conjugates are suitable for the detection of mouse or rabbit primary antibodies. The Multiplex Detection is suitable for a mouse and rabbit primary antibody cocktail. ONCORE Detection is to be used in conjunction with the appropriate ONCORE Chromogens, available below.

ONCORE Detection is prepared using a proprietary micro-polymer technology that provides a highly sensitive detection system, with minimal background staining. As these detections do not use biotin or streptavidin, non-specific staining associated with endogenous biotin is avoided. ONCORE Detection is ready-to-use for staining protocols on the ONCORE Automated Slide Stainer.

ONCORE Mouse HRP Detection

$751.00 Add to cart

ONCORE Mouse AP Detection

$798.00 Add to cart

ONCORE Rabbit HRP Detection

$751.00 Add to cart

ONCORE Rabbit AP Detection

$798.00 Add to cart

ONCORE Multiplex Detection 2

$891.00 Add to cart

Oncore Chromogens

ONCORE Chromogens produce a colored reaction product that is visible by light microscopy when applied to an enzyme-antibody conjugate as part of an IHC procedure on the ONCORE Automated Slide Stainer. ONCORE Chromogens are available for both HRP (horseradish peroxidase) and AP (alkaline phosphatase) detection systems. DAB is a widely used chromogen for HRP detection systems while Fast Red is a widely used chromogen for AP detection systems. ONCORE Chromogens are to be used in conjunction with the appropriate ONCORE Detection, available above.

ONCORE DAB Chromogen Kit

$184.00 Add to cart

ONCORE Fast Red Chromogen Kit

$98.00 Add to cart

Reagents

Antigen Retrieval 1 (AR1), high pH

Antigen Retrieval 1 (AR1), high pH is a Tris-EDTA buffer (pH 9.0) which is capable of partially breaking the covalent bonds of formalin-fixed tissue, as part of an IHC staining procedure on the ONCORE Automated Slide Stainer. Pretreatment of FFPE tissues with Antigen Retrieval 1 (AR1), high pH can significantly increase staining intensity. The solution is provided ready-to-use and is intended to be applied as defined by the staining protocols on the ONCORE Automated Slide Stainer.

Antigen Retrieval 1 (AR1), high pH

$56.00 Add to cart

Antigen Retrieval 2 (AR2), low pH

Antigen Retrieval 2 (AR2), low pH is a citrate buffer (pH 6.0) which is capable of partially breaking the covalent bonds of formalin-fixed tissue, as part of an IHC staining procedure on the ONCORE Automated Slide Stainer. Pretreatment of FFPE tissues with Antigen Retrieval 2 (AR2), low pH can significantly increase staining intensity. The solution is provided ready-to-use and is intended to be applied as defined by the staining protocols on the ONCORE Automated Slide Stainer.

Antigen Retrieval 2 (AR2), low pH

$56.00 Add to cart

Dewax Solution Kit

Dewax Solutions 1a, 1b and 2 (DS1a, DS1b, DS2) and Dewax Solution Buffer (DS Buffer) are water-based solutions for the removal of paraffin wax from FFPE tissue specimens, as part of an IHC staining procedure on the ONCORE Automated Slide Stainer. Removal of paraffin wax must be performed prior to antigen retrieval and the application of reagents for immunostaining. The solutions are provided ready-to-use and are intended to be applied sequentially as defined by the staining rotocols on the ONCORE Automated Slide Stainer.

Dewax Solution Kit

$56.00 Add to cart

DS Enzyme

DS Enzyme is a ready-to-use solution of the proteolytic enzyme pepsin, which may be useful as a pretreatment step for epitope retrieval in FFPE tissue, as part of an IHC staining procedure on the ONCORE Automated Slide Stainer. Pretreatment of FFPE tissues with DS Enzyme can significantly increase staining intensity. The solution is provided ready-to-use and is intended to be applied as defined by the staining protocols on the ONCORE Automated Slide Stainer.

DS Enzyme

$32.00 Add to cart

Wash Buffer

Wash Buffer is used to rinse tissue sections after each incubation step, effectively removing the previous reagent and preparing the tissue for application of the following reagent. Wash Buffer is a Tris-buffered solution (pH (7.6-7.8) with added surfactant to improve spreading and a preservative to inhibit microbial growth. Wash Buffer is provided ready-to-use and is intended to be applied as designed by the staining protocols on the ONCORE Automated Slide Stainer.

Wash Buffer

$58.00 Add to cart

Universal Negative Control Serum

Universal Negative Control Serum is a buffered solution of mouse IgG and rabbit IgG antibodies intended for use as a negative control reagent on FFPE tissues in an IHC procedure performed on Biocare Medical’s ONCORE Automated Slide Stainer and visualized by light microscopy. Universal Negative Control Serum should be used in place of primary antibody to confirm performance of mouse and rabbit detection systems and evaluate any staining that may occur in the absence of primary antibody. Universal Negative Control Serum is provided ready-to-use and is intended to be applied as defined by the staining protocols on the ONCORE Automated Slide Stainer.

Universal Negative Control Serum

$94.00 Add to cart

Supplies

Chamber Cleaning Kit

The Chamber Cleaning Kit consists of three solutions intended for cleaning the tubing and chamber surfaces that come in contact with 3,3’-diaminobenzidine (DAB) in the ONCORE Automated Slide Stainer. During routine staining, DAB residue may be left behind on these surfaces. Regular use of the Chamber Cleaning Kit is recommended to remove DAB residue and prevent a hue on slides. Each Chamber Cleaning Kit is good for 8 cleaning cycles. Please refer to the ONCORE Automated Slide Staining System User Manual for recommended cleaning schedule.

Chamber Cleaning Kit

$495.00 Add to cart

ONCORE Improv Reagent Vials

The ONCORE Improv Reagent Vials are “user-fillable” vials that are designed for the utilization of alternate primary antibodies not offered within the ONCORE reagent line on the ONCORE Automated Slide Staining System.

ONCORE Improv Reagent Vials

$700.00$919.00 Select options

Tubing Cleaning Kit

The Tubing Cleaning Kit consists of two solutions for removing DAB precipitate from the reagent aspirating tubing (Z1 tubing) and residual wax from the waste tubing (Z2 tubing) in the ONCORE Automated Slide Stainer. During routine staining, DAB residue may be left behind on tubing surfaces. Paraffin wax may also build up in the waste tubing. Regular use of the Tubing Cleaning Kit is recommended to remove DAB residue to ensure effective reagent extractions through the waste tubing. Each Tubing Cleaning Kit is good for 3 cleaning cycles. Please refer to the ONCORE Automated Slide Staining System User Manual for the recommended cleaning schedule.

Tubing Cleaning Kit

$250.00 Add to cart

Label Printer Ribbon

Label Printer Ribbon

$78.00 Add to cart

Slide Label Roll

Slide Label Roll

$284.00 Add to cart

Slide Capacity 36 slides
Heating Capacity Room temperature to 105 °C
On-Board Reagent Capacity 40 vials (15 or 7 ml)
Dispense Volume 200 µl
Waste Separation Separated hazardous and non-hazardous
LIS Connectivity Compatible with XML and HL-7 messaging standards
Electrical 100-240 V; 50/60 Hz; 900 W
Dimensions (W x H x D) 33” x 22” x 24” / 84 cm x 56 cm x 61 cm
Weight 110 lbs / 50 kg
Regulatory CE marked, ETL approved
ONCORE Cat. No.
ONCORE Automated Slide Staining System* (110V Markets) ONC0001-110V
ONCORE Automated Slide Staining System (220V Markets) ONC0001-220V

*Includes ONCORE Slide Stainer, desktop PC, mouse, software, slide label printer, report printer, UPS, and accessory buffer and waste containers (ONC0001-110V only)
Note:  The ONCORE is available for sale in North America, Central America, South America, India, Indonesia, Turkey and Japan.