p21
This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. Studies have shown that the relocalization of p21WAFI/CIPI from the nucleus to the cytoplasm, results in a loss of p21WAFI/CIPI tumor suppressor functions. This loss of function has shown to be a negative prognostic factor in breast cancers, renal carcinoma, gastric and colon cancer. Therefore, careful analysis of p21 staining patterns is required for interpretation. Either the reduction of nuclear staining and/or cytoplasmic staining may be useful for prognostication.
| Ordering Information |
Catalog Number |
Volume |
| Concentrate |
CM 354 |
CK |
| Predilute |
N/A |
N/A |
| intelliPATH™ |
N/A |
N/A |
| VP Echelon |
N/A |
N/A |
| A / AK = 0.1 ml |
B / BK = 0.5 ml |
C / CK = 1.0 ml |
G5 = 5.0 ml |
AA = 6.0 ml |
H / G25 = 25 ml |
L = 100 ml |
