p63 (PulmoPanel™)

Lung squamous cell carcinoma stained with p63 antibody

Tumor protein p63, also known as transformation-related protein 63 is a protein that in humans is encoded by the TP63 gene. Many studies have shown that p63 is a sensitive (90%) and fairly specific marker for squamous cell carcinoma and may be used in distinguishing poorly differentiated lung squamous cell carcinomas (SqCC) from adenocarcinomas. p63 has been shown to mark approximately 5 to 10% of lung adenocarcinomas.

p63 is a nuclear stain and has been specially titered for lung SqCC. This optimized p63 antibody is part of the PulmoPanel™ set used for discriminating between lung adenocarcinoma vs. lung SqCC.

A cocktail of p63 and TRIM29 can also be utilized for lung SqCC and studies have shown that when p63 and/or TRIM29 is expressed in lung SqCC, a 95.4% sensitivity and 100% specificity was achieved, if Napsin A and TTF-1 were both negative in the same case.

*Part of the PulmoPanel™ Kit for diagnosing lung cancer, to order use Cat. No. PPM 435 AAK.
The PulmoPanel™ Kit includes: CK5, Desmoglein 3, Napsin A, p63, TRIM29 and TTF-1.

Specifications  
Intended Use
Source
Species Reactivity ,
Clone
Isotype
Antigen
Cellular Localization
Positive Control
Normal Tissue ,
Abnormal Tissue
Ordering Information Catalog Number Volume
Concentrate N/A N/A
Predilute PM 163 AAK
intelliPATH™ N/A N/A
VP Echelon N/A N/A
A / AK = 0.1 ml B / BK = 0.5 ml C / CK = 1.0 ml G5 = 5.0 ml AA = 6.0 ml H / G25 = 25 ml L = 100 ml
Data Sheets
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