IGF-1R
The Insulin-like Growth Factor 1 Receptor (IGF-1R) is a transmembrane receptor that is activated by Insulin-like Growth Factor (IGF-1) and by the related growth factor IGF-2. It belongs to the large class of tyrosine kinase receptors. IGF-1 stimulates mitosis and inhibits apoptosis thus enhancing cell survival. The IGF-1 receptor is expressed in all cell types and tissues and is highly over-expressed in most malignant tissues. IGF-1 has been shown to induce hypoxia-inducible factor-1 (HIF-1) mediated vascular endothelial growth factor (VEGF) expression. Other studies have shown IGF-1 to be a possible predictive factor for resistance to treatment with anti-EGFR monoclonal antibodies in K-RAS wild type colorectal cancer. Combined IGF-1 and K-RAS analysis may represent an effective strategy for a better selection of responding colorectal cancer patients.
| Ordering Information |
Catalog Number |
Volume |
| Concentrate |
CM 414 |
A, C |
| Predilute |
N/A |
N/A |
| intelliPATH™ |
N/A |
N/A |
| VP Echelon |
N/A |
N/A |
| A / AK = 0.1 ml |
B / BK = 0.5 ml |
C / CK = 1.0 ml |
G5 = 5.0 ml |
AA = 6.0 ml |
H / G25 = 25 ml |
L = 100 ml |
