DOG1
DOG1 is a cell surface protein of unknown function selectively expressed in gastrointestinal stromal tumors (GIST). DOG1 expression has been reported to be a very sensitive and specific marker for GIST in paraffin-embedded tissue. Among GIST cases with KIT mutations, DOG1 detected 11% more cases than CD117. In KIT/CD117 negative and PDGFRA-mutant GIST cases, DOG1 increased the accuracy of GIST diagnosis. This has important clinical implication because most GIST patients can benefit from imatinib mesylate (Gleevec®) treatment. As a result of its localization in the cell membrane, its absence in the majority of normal tissue and its presence in most GIST tissue, DOG1 may be an additional target in the diagnosis and treatment of GIST. DOG1 expression is seen in fewer cases of mesenchymal and epithelial tumors, seminomas and melanomas when compared with CD117.
| Ordering Information |
Catalog Number |
Volume |
| Concentrate |
CM 385 |
A, C |
| Predilute |
PM 385 |
AA |
| intelliPATH™ |
IP 385 |
G10 |
| VP Echelon |
N/A |
N/A |
| A / AK = 0.1 ml |
B / BK = 0.5 ml |
C / CK = 1.0 ml |
G5 = 5.0 ml |
AA = 6.0 ml |
H / G25 = 25 ml |
L = 100 ml |
