BOB-1
BOB-1 (B-cell specific octamer binding protein-1) protein is a B-lymphocyte-specific transcriptional coactivator. It interacts with Oct-1 and Oct-2 transcription factors. BOB-1 and Oct-2 play essential roles in germinal center formation and immunoglobulin production. BOB-1 has been reported to be detectable in all B-cell populations found in reactive lymphoid tissues, the strongest expression being found in germinal center Bcells and plasma cells. BOB-1 and Oct-2 are most useful for the B-lineage determination of CD20-plasmablastic, or primary effusion subtypes of diffuse large Bcell lymphoma (DLBCL). Other studies have shown BOB.1, CD79a and Cyclin E are the most appropriate markers to discriminate classical Hodgkin’s lymphoma from primary mediastinal large B-cell lymphoma. The strong nuclear expression of BOB-1 and Oct-2 by germinal center derived lymphomas makes these antibodies a novel class of broad spectrum B-lineage immunohistochemical markers in the differential diagnosis of lymphomas.
| Ordering Information |
Catalog Number |
Volume |
| Concentrate |
CM 418 |
A, B |
| Predilute |
PM 418 AA |
AA |
| intelliPATH™ |
N/A |
N/A |
| VP Echelon |
N/A |
N/A |
| A / AK = 0.1 ml |
B / BK = 0.5 ml |
C / CK = 1.0 ml |
G5 = 5.0 ml |
AA = 6.0 ml |
H / G25 = 25 ml |
L = 100 ml |
