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WT1 is a protein involved in the induction of Wilms’ Tumor. The WT1 gene, located on 11p13, is inactivated in 5 to 10% of sporadic Wilms’ tumors and in nearly 100% of Denys-Drash patients. In normal tissues, WT1 (mRNA) has been observed in human kidney, spleen and gonadal ridge mesoderm. The WT1 antibody gene has also been observed in Sertoli cells of testes and in granulosa cells of the ovary. In tumors, WT1 has been demonstrated in Wilms’ tumors and in the majority or mesotheliomas. A study indicates WT1 may be a useful tool in distinguishing schwannoma from fibroblastic meningioma.
Wilms’ tumor, mesothelioma
Nuclear, paranuclear and, in some cases, cytoplasmic
Wilms’ tumor, mesothelioma, or normal kidney
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