Vimentin

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Vimentin is the main intermediate filament protein in mesenchymal cells. Vimentin rabbit antibody shows no cross-reactivity with other closely related intermediate filament proteins such as Desmin and GFAP. Vimentin may be useful as an epithelial-mesenchymal transition (EMT) marker, giving an indication of tumor progression and potential for metastasis and is of value in the differential diagnosis of undifferentiated neoplasms including melanoma and sarcoma. Vimentin can also serve as an internal control for formalin-fixed tissues that are over-fixed.

Intended Use

IVD

Species Reactivity

Human

Source

Rabbit Monoclonal

Clone

SP20

Isotype

IgG

Antigen

Vimentin

Localization

Cytoplasmic

Positive Control

Melanoma or sarcoma

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Regulatory Notice: Biocare’s IVD-labeled products comply with US-FDA and European IVDD regulation. Other regions may have additional requirements for such labeling, please contact your local distributor.

1. Caselitz J, et al. Malignant melanomas contain only the vimentin type of intermediate filaments. Virchows Arch A Pathol Anat Histopathol. 1983; 400(1):43-51
2. Leader M, et al. Vimentin: an evaluation of its role as a tumour marker. Histopathology. 1987; 11(1):63-72.
3. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
4. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory workers from occupationally Acquired Infections; Approved guideline-Third Edition CLSI document M29-A3 Wayne, PA 2005.

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