Vimentin

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Vimentin is the main intermediate filament protein in mesenchymal cells. Vimentin antibody shows no cross-reactivity with other closely related intermediate filament proteins such as Desmin and GFAP. Vimentin may be useful as an epithelial-mesenchymal transition (EMT) marker, giving an indication of tumor progression and potential for metastasis and is of value in the differential diagnosis of undifferentiated neoplasms including melanoma and sarcoma. Vimentin can also serve as an internal control for formalin-fixed tissues that are over-fixed.

Intended Use

IVD

Species Reactivity

Human

Source

Mouse Monoclonal

Clone

V9

Isotype

IgG1 /kappa

Antigen

Vimentin

Localization

Variable

Positive Control

Melanoma

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Regulatory Notice: Biocare’s IVD-labeled products comply with US-FDA and European IVDD regulation. Other regions may have additional requirements for such labeling, please contact your local distributor.

1. Urban K, Hewicker-Trautwein M. Fixation-dependent vimentin immunoreactivity of mono- and polyclonal antibodies in brain tissue of cattle, rabbits, rats and mice. Acta Histochem 1994 Dec;96(4):365-377.
2. Battifora H. Assessment of antigen damage in immunohistochemistry. The vimentin internal control. Am J Clin Pathol1991 Nov;96(5):669-671.
3. Carbone A, Gloghini A, Volpe R, Boiocchi M. Anti-vimentin antibody reactivity with Reed-Sternberg cells of Hodgkin’s disease. Virchows Arch A Pathol Anat Histopathol 1990;417(1):43-48.
4. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
5. National Committee for Clinical Laboratory Standards (NCCLS). Protection of laboratory workers from infectious diseases transmitted by blood and tissue; proposed guideline. Villanova, PA 1991;7(9). Order code M29-P.

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