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Thyroid transcription factor-1 (TTF-1 antibody) is a member of the NKX2 family of homeodomain transcription factors. Studies show TTF-1 is expressed in epithelial cells of the thyroid gland and the lung. TTF-1 is detected in primary lung adenocarcinomas and small cell carcinomas. It is absent in mesotheliomas, colon cancer and breast cancer. Studies show a panel of TTF-1, Napsin A and p63 and CK5/6 can sub-classify poorly differentiated areas of non-small cell lung carcinomas. A TTF-1 + p40 cocktail has been reported to differentiate between primary lung squamous cell carcinomas from adenocarcinomas.
TTF-1 (Thyroid transcription factor-1)
Lung adenocarcinoma or thyroid
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