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The expression of Surfactant-apoprotein-A (SP-A) by tumor cells has been shown to be a helpful diagnostic tool for the identification of primary lung carcinomas. Surfactant-apoprotein-A antibody is expressed in pneumocytes II of lung tissue and in a portion of non-small cell lung carcinomas. Immunohistochemically detected SP-A [32E12] in conjunction with thyroid transcription factor-1 (or other lung carcinoma identifying antibodies) may be a useful tool to aid in diagnosing lung malignancies of unknown primary origin.
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