Surfactant apoprotein-A

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The expression of Surfactant-apoprotein-A (SP-A) by tumor cells has been shown to be a helpful diagnostic tool for the identification of primary lung carcinomas. Surfactant-apoprotein-A antibody is expressed in pneumocytes II of lung tissue and in a portion of non-small cell lung carcinomas. Immunohistochemically detected SP-A [32E12] in conjunction with thyroid transcription factor-1 (or other lung carcinoma identifying antibodies) may be a useful tool to aid in diagnosing lung malignancies of unknown primary origin.

Intended Use

IVD

Species Reactivity

Human

Source

Mouse Monoclonal

Clone

32E12

Isotype

IgG2a /kappa

Antigen

Surfactant apoprotein

Localization

Cytoplasmic

Positive Control

Lung carcinoma

1. Zamecnik J, Kodet R. Value of thyroid transcription factor-1 and surfactant apoprotein A in the differential diagnosis of pulmonary carcinomas: a study of 109 cases. Virchows Arch. 2002 Apr;440(4):353-61. Epub 2001 Oct 19.
2. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
3. National Committee for Clinical Laboratory Standards (NCCLS). Protection of laboratory workers from infectious diseases transmitted by blood and tissue; proposed guideline. Villanova, PA 1991;7(9). Order code M29-P.

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