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Smooth Muscle Actin (SMA) antibody recognizes the alpha-smooth muscle isoform of actin. According to studies, it shows no cross-reactivity with actin from fibroblasts (beta- and gamma-cytoplasmic), striated muscle (alpha-sarcomeric) and myocardium (alpha-myocardial). A synthetic peptide corresponding to N-terminus of human alpha-actin was used as immunogen. SMA stains smooth muscle cells in vessel walls, gut wall and myometrium. Myoepithelial cells in breast and salivary glands are also stained as they contain actin. SMA is reportedly useful for identifying tumors arising from smooth muscle and myoepithelial cells.
Human, Mouse, Rat
Smooth Muscle Actin
Blood vessels, leiomyoma or leiomyosarcoma
1. Sheehan M, O’Briain DS. False-positive immunoractivity with muscle-specific actins in non-Hodgkin’s lymphomas. Arch Pathol Lab Med, 1995, Mar;119(3):225-228.
2. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
3. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory workers from occupationally Acquired Infections; Approved guideline-Third Edition CLSI document M29-A3 Wayne, PA 2005. This antibody was produced using EPITOMICS proprietary rabbit monoclonal antibody technology (U.S. Patent No. 5,675,063).