S100 Protein [15E2E2] (M)

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The S100 antibody (21-24kDa) is identified as A and B subunits of S100 protein. S100 belongs to the family of calcium binding proteins such as calmodulin and troponin C. S100A is composed of alpha and beta chains whereas S100B is composed of two beta chains. Antibody S100 stains melanocytes, schwannomas, peripheral neural tissue and astrocytes, and benign and malignant melanomas and their metastases. S100 protein is also expressed in the antigen presenting cells such as the Langerhans cells in skin and interdigitating reticulum cells in the paracortex of lymph nodes. Histocytosis X can also be confirmed by S100 staining. S100 protein is highly soluble and may be eluted from frozen tissue during staining. This monoclonal S100 antibody is excellent for immunohistochemical staining of formalin-fixed, paraffin-embedded tissues

Intended Use


Species Reactivity



Mouse Monoclonal






S100 Protein A and B subunits


Cytoplasmic and nuclear

Positive Control

Melanoma or Schwannoma lymphoblastic leukemia

1. Banerjee SS, Bishop PW, Nicholson CM, Eyden BP. Malignant melanoma showing smooth muscle differentiation. J Clin Pathol, Nov;49(11):950-951, 1996.
2. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
3. National Committee for Clinical Laboratory Standards (NCCLS). Protection of laboratory workers from infectious diseases transmitted by blood and tissue; proposed guideline. Villanova, PA 1991;7(9). Order code M29-P.


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