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The S100 antibody (21-24kDa) is identified as A and B subunits of S100 protein. S100 belongs to the family of calcium binding proteins such as calmodulin and troponin C. S100A is composed of alpha and beta chains whereas S100B is composed of two beta chains. Antibody S100 stains melanocytes, schwannomas, peripheral neural tissue and astrocytes, and benign and malignant melanomas and their metastases. S100 protein is also expressed in the antigen presenting cells such as the Langerhans cells in skin and interdigitating reticulum cells in the paracortex of lymph nodes. Histocytosis X can also be confirmed by S100 staining. S100 protein is highly soluble and may be eluted from frozen tissue during staining. This monoclonal S100 antibody is excellent for immunohistochemical staining of formalin-fixed, paraffin-embedded tissues
S100 Protein A and B subunits
Cytoplasmic and nuclear
Melanoma or Schwannoma lymphoblastic leukemia
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