S100 Protein Cocktail

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S100 belongs to the family of calcium binding proteins such as calmodulin and troponin C. The S100 Protein Cocktail antibody stains melanocytes, schwannomas, peripheral neural tissue, astrocytes, benign and malignant melanomas and their metastases. S100 protein is also expressed in the antigen presenting cells such as the Langerhan’s cells in skin and interdigitating reticulum cells in the paracortex of lymph nodes. S100 protein is highly soluble and may be eluted from frozen tissue during staining. The S100 monoclonal cocktail is potentially more sensitive than other S100 single clone antibodies and may be an excellent pan-melanoma marker.

Intended Use

IVD

Species Reactivity

Human, Mouse, Rat

Source

Mouse Monoclonal

Clone

15E2E2 + 4C4.9

Isotype

IgG2ak + IgG2a

Antigen

S100 Protein

Localization

Cytoplasmic and nuclear

Positive Control

Melanoma

1. Banerjee SS, et al. Malignant melanoma showing smooth muscle differentiation. J Clin Pathol. 1996 Nov;49(11):950-1.
2. Argenyi ZB, et al. S-100 protein-negative malignant melanoma: fact or fiction? A light- microscopic and immunohistochemical study. Am J Dermatopathol. 1994 Jun;16 (3):233-40.
3. Fernando SS, Johnson S, Bate J. Immunohistochemical analysis of cutaneous malignant melanoma: comparison of S-100 protein, HMB45 monoclonal antibody and NKI/C3 monoclonal antibody. Pathology. 1994 Jan;26(1):16-9.
4. Tousignant J, et al. Immunohistochemical characteristics of malignant melanoma. A study of 40 cases and review of the literature. Arch Anat Cytol Pathol. 1990; 38(1-2):5 -10.
5. Miettinen M, Franssila K. Immunohistochemical spectrum of malignant melanoma. The common presence of keratins. Lab Invest. 1989 Dec;61(6):623-8.
6. Fitzgibbons PL, et al. Primary mucosal malignant melanoma: an immunohistochemical study of 12 cases with comparison to cutaneous and metastatic melanomas. Hum Pathol. 1989 Mar;20(3):269 -72.
7. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
8. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory Workers from Occupationally Acquired Infections; Approved guideline-Third Edition CLSI document M29-A3 Wayne, PA 2005.

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