S100 belongs to the family of calcium binding proteins such as calmodulin and troponin C. The S100 antibody stains Schwannomas, ependymomas, astrogliomas, almost all benign and malignant melanomas and their metastases. S100 protein is also expressed in the antigen presenting cells such as the Langerhan’s cells in skin and interdigitating reticulum cells in the paracortex of lymph nodes. S100 protein is highly soluble and may be eluted from frozen tissue during staining, however it is excellent for immunohistochemical staining of formalin-fixed, paraffin-embedded (FFPE) tissues.
Human, Mouse, Rat
Cytoplasmic and nuclear
Melanoma or Schwannoma
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