S100 Protein (P)

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S100 belongs to the family of calcium binding proteins such as calmodulin and troponin C. The S100 antibody stains Schwannomas, ependymomas, astrogliomas, almost all benign and malignant melanomas and their metastases. S100 protein is also expressed in the antigen presenting cells such as the Langerhan’s cells in skin and interdigitating reticulum cells in the paracortex of lymph nodes. S100 protein is highly soluble and may be eluted from frozen tissue during staining, however it is excellent for immunohistochemical staining of formalin-fixed, paraffin-embedded (FFPE) tissues.

Intended Use

IVD

Species Reactivity

Human, Mouse, Rat

Source

Rabbit Polyclonal

Clone

N/A

Isotype

N/A

Antigen

S100 Protein

Localization

Cytoplasmic and nuclear

Positive Control

Melanoma or Schwannoma

1. Banerjee SS, Bishop PW, Nicholson CM, Eyden BP. Malignant melanoma showing smooth muscle differentiation. JClin Pathol, Nov;49(11):950-951, 1996.
2. Argenyi ZB et al. S-100 protein-negative malignant melanoma: fact or fiction? A light-microscopic and immunohistochemical study. Am J. Dermatopathol., Jun;16 (3):233-240, 1994.
3. Fernando SS, Johnson S, Bate J. Immunohistochemical analysis of cutaneous malignant melanoma: comparison of S-100 protein, HMB45 monoclonal antibody and NKI/C3 monoclonal antibody. Pathology, Jan;26(1):16-19, 1994.
4. Tousignant J et aL. Immunohistochemical characteristics of malignant melanoma. A study of 40 cases and review of the literature. Arch Anat Cytol Pathol, 38(1-2):5 -10, 1990.
5. Miettinen M, Franssila K. Immunohistochemical spectrum of malignant melanoma.The common presence of keratins. Lab Invest, Dec;61(6):623-628, 1989.
6. Fitzgibbons PL, Chaurushiya PS, Nichols PW, Chandrasoma PT, Martin SE. Primary mucosal malignant melanoma: an immunohistochemical study of 12 cases with comparison to cutaneous and metastatic melanomas. Hum Pathol, Mar;20(3):269 -272, 1989.
7. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
8. National Committee for Clinical Laboratory Standards (NCCLS). Protection of laboratory workers from infectious diseases transmitted by blood and tissue; proposed guideline. Villanova, PA 1991;7(9). Order code M29-P.

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