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Rodent Decloaker is a novel heat retrieval solution for rodent tissues that allows the end-user to block for endogenous mouse and rat IgG, block for non-specific background staining, block for endogenous peroxidase and at the same time perform antigen retrieval. Rodent Decloaker is compatible with virtually all types of primary antibodies. Rodent Decloaker can be used with Biocare’s digital electric pressure cooker (Decloaking Chamber). Antibody titers are doubled and tripled when compared to citrate buffer, pH 6.0. Rodent Decloaker incorporates Assure™ technology y, a color-coded high temperature pH indicator solution. The end-user is assured by visual inspection that the solution is at the correct dilution and pH. This product is specially formulated for superior pH stability at high temperatures and will help prevent the possibility of losing pH sensitive antigens. Rodent Decloaker is non-toxic, non-flammable and sodium azide and thimerosal free.