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Kappa and / or Lambda light chain mRNA may be detected in normal and neoplastic B-cells in human lymphoid tissue. Restriction of either Kappa or Lambda mRNA denotes monoclonality of lymphoid neoplasms and is useful in distinguishing between neoplastic and reactive lymphoid proliferations. The Dual Kappa / Lambda probe cocktail can simultaneously detect polyclonal plasma cell infiltrates in a single tissue section. The technique of in situ hybridization offers an important advantage over immunohistochemistry, as it virtually lacks background, and allows a clean and sharp viewing of the histological preparation. It is also useful to differentiate cells that have absorbed immunoglobulins, and are therefore detectable by immunohistochemistry, but in fact do not produce immunoglobulin, as occurs with the Reed-Sternberg cells of Hodgkin’s disease.
20 tests at 20 microliters per test