RB1 (13q14.2) Green FISH Probe

SKU: HFI7315A Categories: ,

Loss of the 13q region or even the whole of chromosome 13 is very common in cases of multiple myeloma (MM). Deletions of the RB1 gene are common in a variety of hematological malignancies including chronic lymphocytic leukemia (CLL), acute myelocytic leukemia (AML) and MM1,2,3.

FOR DISTRIBUTION OUTSIDE THE UNITED STATES ONLY

Intended Use

IVD

Volume

100 µl

Species Reactivity

Human

Color

Green

Download OUS Datasheet

Legal Notice

IVD is NOT for Sale in the United States but may be available in certain countries outside of the United States, please contact your local distributor for more information.

1. Comprehensive genetic characterization of CLL: a study on 506 cases analysed with chromosome banding analysis, interphase FISH, IgV(H) status and immunophenotyping. Haferlach C, Dicker F, Schnittger S, Kern W, Haferlach T. Leukemia 2007, 21:2442-2451
2. Monoallelic and Biallelic Deletions of 13q14 in a Group of 36 CLL Patients Investigated by CGH Haematological Cancer and SNP Array (8x60K).B. Grygalewicz, R. Woroniecka, J. Rygier, K. Borkowska, A. Labak, B. Nowakowska, B. Pienkowska-Grela. International Science Index Vol:2, No:9, 2015.
3. Abnormalities of the retinoblastoma gene in the pathogenesis of acute leukemia. Ahuja HG, Jat PS, Foti A, Bar-Eli M, Cline MJ. Blood. 1991 Dec 15;78(12):3259-68.
4. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory workers from occupationally Acquired Infections; Approved Guideline-Fourth Edition CLSI document M29-A4 Wayne, PA 2014.