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Loss of the 13q region or even the whole of chromosome 13 is very common in cases of multiple myeloma (MM). Deletions of the RB1 gene are common in a variety of hematological malignancies including chronic lymphocytic leukemia (CLL), acute myelocytic leukemia (AML) and MM1,2,3.
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1. Comprehensive genetic characterization of CLL: a study on 506 cases analysed with chromosome banding analysis, interphase FISH, IgV(H) status and immunophenotyping. Haferlach C, Dicker F, Schnittger S, Kern W, Haferlach T. Leukemia 2007, 21:2442-2451
2. Monoallelic and Biallelic Deletions of 13q14 in a Group of 36 CLL Patients Investigated by CGH Haematological Cancer and SNP Array (8x60K).B. Grygalewicz, R. Woroniecka, J. Rygier, K. Borkowska, A. Labak, B. Nowakowska, B. Pienkowska-Grela. International Science Index Vol:2, No:9, 2015.
3. Abnormalities of the retinoblastoma gene in the pathogenesis of acute leukemia. Ahuja HG, Jat PS, Foti A, Bar-Eli M, Cline MJ. Blood. 1991 Dec 15;78(12):3259-68.
4. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory workers from occupationally Acquired Infections; Approved Guideline-Fourth Edition CLSI document M29-A4 Wayne, PA 2014.