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PU.1 regulates the expression of immunoglobulin and other genes that are important for B-cell development. It is expressed in B-lymphocytes, macrophages and appears to be involved in the control of monocyte development. Results have shown a lack of PU.1 expression by neoplastic cells in classic Hodgkin’s disease (cHD) but not in lymphocyte prevalent HD. The lack of PU.1 protein expression in cHD likely contributes to the lack of immunoglobulin expression and incomplete B-cell phenotype characteristic of the Reed-Sternberg cells in cHD. Therefore, PU.1 antibody may represent a useful marker to aid the interpretation of lymphocyte-predominant Hodgkin’s disease.
Lymphocyte Predominant Hodgkin’s