Progesterone Receptor (PR) [PgR636]

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The progesterone receptor is a member of the steroid-receptor family. Steroid hormones bind to intracellular receptors and these receptors can bind to DNA and regulate gene expression directly. Research has shown PR to reflect intact estrogen regulatory machinery and predicts a higher response to endocrine therapy than ER alone. A study has implicated the loss of Progesterone Receptor [PgR636] antibody expression as an independent predictor of poor prognosis and lymph node metastasis in endometrial carcinomas.

Intended Use

ASR

Species Reactivity

Human

Source

Mouse Monoclonal

Clone

PgR636

Isotype

IgG1/kappa

Antigen

Progesterone Receptor

Localization

Nuclear

Positive Control

Breast cancer

Download OUS Datasheet

Legal Notice

IVD is NOT for Sale in the United States but may be available in certain countries outside of the United States, please contact your local distributor for more information.

1. Press M, Spaulding B, Groshen S, Kaminsky D, Hagerty M, Sherman L, Christensen K, Edwards DP. Comparison of different antibodies for detection of progesterone receptor in breast cancer steroids. Steroids. 2002 Aug; 67(9):799-813.
2. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
3. National Committee for Clinical Laboratory Standards (NCCLS). Protection of laboratory workers from infectious diseases transmitted by blood and tissue; proposed guideline. Villanova, PA 1991; 7(9). Order code M29-P.

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