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The progesterone receptor is a member of the steroid-receptor family. Steroid hormones bind to intracellular receptors and these receptors can bind to DNA and regulate gene expression directly. Research has shown PR to reflect intact estrogen regulatory machinery and predicts a higher response to endocrine therapy than ER alone. A study has implicated the loss of Progesterone Receptor [PgR636] antibody expression as an independent predictor of poor prognosis and lymph node metastasis in endometrial carcinomas.
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