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PIK3CA mutations have been discovered in many cancers including, colon, breast, endometrial, brain, skin, gastric, lung and thyroid1,2. Extensive studies have led researchers to believe that PIK3CA is one of the most commonly mutated oncogenes in human cancers3. These amplification events can be readily identified using appropriate FISH probes.
1. High frequency of mutations of the PIK3CA gene in human cancers. Samuels Y, Wang Z, Bardelli A, Silliman N, Ptak J, Szabo S, Yan H, Gazdar A. Prostate Cancer Prostatic Dis. 2010 Dec;13(4):311-5. doi: 10.1038/pcan.2010.31. Epub 2010 Sep 7.
2. PIK3CA gene amplification in Japanese non-small cell lung cancer. Kawano O, Sasaki H, Okuda K, Yukiue H, Yokoyama T, Yano M, Fujii Y.Lung Cancer. 2007 Oct; 58(1):159-60.
3. Oncogenic Mutations of PIK3CA in Human Cancers. Yardena Samuels and Todd Waldman. Curr Top Microbiol Immunol.2010; 347: 21–41.
4. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory workers from occupationally Acquired Infections; Approved Guideline-Fourth Edition CLSI document M29-A4 Wayne, PA 2014.