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Protein Gene Product 9.5 (PGP9.5) is also known as ubiquitin C-terminal hydrolase 1 (UCHL-1). Expression of PGP9.5 is highly specific to neurons and to cells of the diffuse neuroendocrine system and their tumors. It is estimated that PGP9.5 antibody comprises 1-2% of total soluble proteins in the brain. Immunohistochemistry of routinely processed neuronal tissues has identified central and peripheral nerve fibers of all sizes. PGP9.5 has been identified in renal tubule, spermatogonia, Leydig cells of the testis and in pregnant and non-pregnant corpus luteum.
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