PGP9.5

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Protein Gene Product 9.5 (PGP9.5) is also known as ubiquitin C-terminal hydrolase 1 (UCHL-1). Expression of PGP9.5 is highly specific to neurons and to cells of the diffuse neuroendocrine system and their tumors. It is estimated that PGP9.5 antibody comprises 1-2% of total soluble proteins in the brain. Immunohistochemistry of routinely processed neuronal tissues has identified central and peripheral nerve fibers of all sizes. PGP9.5 has been identified in renal tubule, spermatogonia, Leydig cells of the testis and in pregnant and non-pregnant corpus luteum.

Intended Use

IVD

Species Reactivity

Mouse, Rat

Source

Mouse Monoclonal

Clone

31A3

Isotype

IgG1

Antigen

PGP9.5

Localization

Cytoplasmic

Positive Control

Brain

1. Wilson PO et al. The immunolocalization of protein gene product 9.5 using rabbit polyclonal and mouse monoclonal antibodies. Br J Exp Pathol. 1998 Feb; 69(1): 91 -104.
2. Romeo HE et al. Protein gene product (PGP) 9.5 immunoreactivity in nerve fibers and pinealocytes of guinea pig pineal gland: interrelationship with tyrosine… Cell Tissue Res. 1993 Mar; 271(3): 477-84.
3. Krammer HJ et al. Immunohistochemical visualization of the enteric nervous system using antibodies against protein gene product (PGP) 9.5. Ann Anat. 1993 Aug; 175 (4):321-5.
4. Ramos-Vara JA, Miller MA. Immunohistochemical detection of protein gene product 9.5 (PGP 9.5) in canine epitheliotropic T-cell lymphoma (mycosis fungoides). Vet Pathol. 2007 Jan; 44(1): 74-9.
5. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
6. National Committee for Clinical Laboratory Standards (NCCLS). Protection of laboratory workers from infectious diseases transmitted by blood and tissue; proposed guideline. Villanova, PA 1991;7(9). Order code M29-P.

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